Synthesis, Characterization, and Biological Evaluation of Some Novel Thiosemicarbazones as Possible Antibacterial and Antioxidant Agents

Abstract

<div><p> </p><p>The synthesis and characterization of 18 novel thiosemicarbazones have been investigated as part of a research program on development of compounds with antibacterial and antioxidant activities. Among the tested compounds, 2-(4-hydroxybenzylidene)-<i>N</i>-[4-(trifluoromethoxy)phenyl]hydrazine carbothioamide (<b>3g</b>) and 2-(thiophen-2-ylmethylidene)-<i>N</i>-[4-(morpholin-4-yl)phenyl]hydrazine carbothioamide (<b>4b</b>) showed excellent inhibition potency at low concentration (0.5 μg/mL) against Gram-positive pathogens <i>(Enterococcus faecalis</i> and <i>Staphylococcus aureus)</i>. All tested compounds were also found to possess antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation.</p><p> [Supplementary materials are available for this article. Go to the publisher's online edition of <i>Phosphorus, Sulfur, and Silicon and the Related Elements</i> for the following free supplemental files: Additional text, tables, and figures.]</p></div