Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intral
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esional corticosteroid injections.
Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and develop
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ment of a descriptive meta-analysis of the results.
Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a
male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone
acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result,
14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Consider
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ing the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive
central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections.
Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treat
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ment option for central giant cell lesion
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