The INTERnational Study on Primary Angiitis of the CEntral nervous system--a call to the world

Abstract

Treatment of Primary Angiitis of the CNS (PACNS) is a challenge aiming at minimizing the risk of treatment failure and recurrent vasculitis while avoiding adverse effects of immunosuppressive agents. Identification of markers of outcome may help tailor immunosuppressive therapy. We designed an observational, prospective, multicenter, cohort study, the INTERnational Study of Primary Angiitis of the CEntral nervous system (INTERSPACE), whose primary objective is to identify predictors of death and dependence (modified Rankin Scale: 3–6) at the end of clinical follow-up (≥one-year following recruitment)