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No major host genetic risk factor contributed to A(H1N1)2009 influenza severity

By Koldo Garcia-Etxebarria, María Alma Bracho, Juan Carlos Galán, Tomás Pumarola, Jesús Castilla, Raul Ortiz de Lejarazu, Mario Rodríguez-Dominguez, Inés Quintela, Núria Bonet, Marc Garcia-Garcerà, Àngela Domínguez García, Fernando González-Candelas and Francesc Calafell

Abstract

While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10−8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course

Topics: Grip, Genòmica, Factors de risc en les malalties, Estudi de casos, Influenza, Genomics, Risk factors in diseases, Case studies
Publisher: Public Library of Science (PLoS)
Year: 2016
DOI identifier: 10.1371/journal.pone.0135983
OAI identifier: oai:diposit.ub.edu:2445/100545
Journal:

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