Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

Fiedler, Hans-Peter; Bruntner, Christina; Riedlinger, Julia; Bull, Alan T.; Knutsen, Gjert; Goodfellow, Michael; Jones, Amanda L.; Maldonado, Luis A.; Pathom-aree, Wasu; Beil, Winfried; Schneider, Kathrin; Keller, Simone; Sussmuth, Roderich D.

oai:kar.kent.ac.uk:7332

Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

Authors: Hans-Peter Fiedler
Christina Bruntner
Julia Riedlinger
Alan T. Bull
Gjert Knutsen
Michael Goodfellow
Amanda L. Jones
Luis A. Maldonado
Wasu Pathom-aree
Winfried Beil
Kathrin Schneider
Simone Keller
Roderich D. Sussmuth
Publication date: 1 March 2008
Publisher
Doi

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines

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oai:kar.kent.ac.uk:7332

Last time updated on 23/02/2012

This paper was published in Kent Academic Repository.

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