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Proximicin A, B and C, novel aminofuran antibiotic and anticancer compounds isolated from marine strains of the actinomycete Verrucosispora

By Hans-Peter Fiedler, Christina Bruntner, Julia Riedlinger, Alan T. Bull, Gjert Knutsen, Michael Goodfellow, Amanda L. Jones, Luis A. Maldonado, Wasu Pathom-aree, Winfried Beil, Kathrin Schneider, Simone Keller and Roderich D. Sussmuth

Abstract

A family of three novel aminofuran antibiotics named as proximicins was isolated from the marine Verrucosispora strain MG-37. Proximicin A was detected in parallel in the marine abyssomicin producer "Verrucosispora maris" AB-18-032. The characteristic structural element of proximicins is 4-amino-furan-2-carboxylic acid, a hitherto unknown gamma-amino acid. Proximicins show a weak antibacterial activity but a strong cytostatic effect to various human tumor cell lines

Topics: Q
Year: 2008
DOI identifier: 10.1038/ja.2008.125
OAI identifier: oai:kar.kent.ac.uk:7332
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