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Immunohistological analysis of Rosai-Dorfman histiocytosis. A disease of S-100 + CD1-histiocytes

By F. Bonetti, M. Chilosi, F. Menestrina, A. Scarpa, P. G. Pelicci, E. Amorosi, L. Fiore-Donati and D. M. Knowles


Five cases of Rosai-Dorfman histiocytosis (RDH) (also called Sinus Histiocytosis with Massive Lymphoadenopathy; SHML) have been studied by immunohistochemical methods with heteroantisera and monoclonal antibodies. One case was also studied by Southern blot hybridization analysis with DNA probes specific for T cell receptor beta chain and immunoglobulin heavy chain. Immunophenotyping of large histiocytes, characteristic of RDH, evidenced the presence of S-100 protein and the absence of CD1 and other markers usually found in histiocytes and macrophages. DNA hybridization study showed the absence of clonal T or B lymphoid populations

Topics: Antigens, Surface, Lymphatic Diseases, Antigens, Differentiation, T-Lymphocyte, S100 Proteins, Humans, DNA, Histocytochemistry, Immunochemistry, Histiocytes, Lymph Nodes, Settore MED/04 - Patologia Generale
Publisher: 'Springer Science and Business Media LLC'
Year: 1987
DOI identifier: 10.1007/BF00712736
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