Multifunctional Nanoparticles for Targeted Chemophotothermal Treatment of Cancer Cells

Abstract

Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)?poly(lactic-co-glycolic acid)?Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive targeting with their HER-free counterparts (DOX-PLGA-Au H-S NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that were treated with the HER-conjugated particles (see picture).This work was financially supported by NRF through the National Core Research Center for Nanomedical Technology (Grant No. R15-2004-024-00000-0) and by Basic Science Research Program through the NRF funded by the Ministry of Education, Science and Technology (2010-0003946)