Identification of signaling pathways in early mammary gland development by mouse genetics

The mammary gland develops as an appendage of the ectoderm. The prenatal stage of mammary development is hormone independent and is regulated by sequential and reciprocal signaling between the epithelium and the mesenchyme. A number of recent studies using human and mouse genetics, in particular targeted gene deletion and transgenic expression, have identified some of the signals that control specific steps in development. This process involves cell specification and proliferation, reciprocal tissue interactions and cell migration. Since some of these events are recapitulated during tumorigenesis, an understanding of these signaling pathways may contribute to the development of targeted therapies and novel drugs

Cancer Report 2008

Welcome Letter by the Directors of the Cancer Center 2-3 Stories from cancer survivors 4-5 Prostate Cancer 6-7 Kidney Cancer 8 Bladder Cancer 9 Activity Report 10-11 Cancer Research 12-13 Retirees 13 Quality Cancer Care 14-15 Survivorship 16 CLIMB® Program 17 Drive Through Colon Cancer Screening saves lives 18 Generous Gifts Changing Lives 19 Innovative Care 2

Cancer Report 2007

Welcome letter by Cancer Center Directors 2-3 Breast Cancer Report 4-5 Analysis of 2007 Activity Report 6-9 Research 10-11 Our Story of Quality 12-13 Generous Gifts Changing Lives 14-15 About Our Cover 1

Cancer Report 2015

Cancer Registry Statistics 1 Welcome 2-3 Mayo Clinic Cancer Care Network 3 The burden is lighter when shared 4-5 Diagnosis 6 Genetics 6 Center of Care 7 Lymphoma 8-9 Infusion Pharmacy 10 Chemotherapy Infusion 11 Animal-Assisted Therapy 12 Palliative Care 13 Psychosocial & Emotional Support 13 Oncology Nursing14-15 Spiritual Care 16 Survivorship Program 17 Family, Friends, Faith & Medicine 18-19 Diffuse Large B-Cell Lymphoma Study 20-21 Clinical Achievements 21 The Power of Philanthrop