Synthesis and anticancer property of one Ce(III) compound based on 5-(2-pyrazinyl)tetrazole-2-acetic acid
Abstract
<p>Mononuclear [Ce(pztza)<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>](pztza)·H<sub>2</sub>O (<b>1</b>) (pztza = 5-(2-pyrazinyl)tetrazole-2-acetato) has been prepared and characterized by IR, elemental analysis and single-crystal X-ray diffraction. PEG<sub>-5000</sub> (poly(ethyleneglycol<sub>-5000</sub>)) coated [Ce(pztza)<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>](pztza)·H<sub>2</sub>O nanoparticles (NPs) can disperse into distilled water. <i>In vitro</i> study on Hela cells shows that Hpztza is nontoxic while [Ce(pztza)<sub>2</sub>(H<sub>2</sub>O)<sub>6</sub>](pztza)·H<sub>2</sub>O NPs show high toxicity with half-maximal inhibitory concentration (IC<sub>50</sub>) of 17 μg/mL (1.93 × 10<sup>−5</sup> M). In addition, such NPs can inhibit the migration of Hela cells effectively.</pSimilar works
This paper was published in FigShare.
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