Synthesis of Arylphosphonates via Palladium-Catalyzed Coupling Reactions of Aryl Imidazolylsulfonates with H-Phosphonate Diesters

Abstract

A palladium-catalyzed reaction of an aryl imidazolylsulfonate with an H-phosphonate diester in the presence of DPPP and iPr2NEt is described. The reactions proceed efficiently to generate the corresponding arylphosphonates in good to excellent yields. The advantages of this method include good substrate generality, high efficiency, and experimental ease

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The Francis Crick Institute

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Last time updated on 16/03/2018

This paper was published in The Francis Crick Institute.

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