textjournal article
3-Arylamino and 3-Alkoxy-nor-β-lapachone Derivatives: Synthesis and Cytotoxicity against Cancer Cell Lines
Abstract
Several 3-arylamino and 3-alkoxy-nor-β-lapachone derivatives were synthesized in moderate to high yields and found to be highly potent against cancer cells SF295 (central nervous system), HCT8 (colon), MDA-MB435 (melanoma), and HL60 (leukemia), with IC50 below 2 μM. The arylamino para-nitro and the 2,4-dimethoxy substituted naphthoquinones showed the best cytoxicity profile, while the ortho-nitro and the 2,4-dimethoxy substituted ones were more selective than doxorubicin and similar to the precursor lapachones, thus emerging as promising new lead compounds in anticancer drug development- Text
- Journal contribution
- Biochemistry
- Medicine
- Cell Biology
- Genetics
- Neuroscience
- Pharmacology
- Evolutionary Biology
- Cancer
- Hematology
- Infectious Diseases
- Chemical Sciences not elsewhere classified
- Information Systems not elsewhere classified
- LinesSeveral
- HL 60
- cancer cells SF 295
- naphthoquinone
- Derivative
- cytoxicity profile
- melanoma
- 2 μ M
- Arylamino
- precursor lapachones
- derivative
- dimethoxy
- Cytotoxicity
- HCT
- compound
- leukemia
- arylamino
- anticancer drug development
- IC 50
- yield
- doxorubicin
- Synthesi
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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