textjournal article
Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells
Abstract
A novel approach to circumvent multidrug resistance is hybridization of natural products in dimers. We analyzed homodimers of two artesunic acid molecules and heterohybrids of artesunic acid and betulin in human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR5000 leukemia cells. Multidrug-resistant cells were not cross-resistant to the novel compounds. Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species- Text
- Journal contribution
- Biochemistry
- Medicine
- Microbiology
- Pharmacology
- Evolutionary Biology
- Cancer
- Hematology
- Infectious Diseases
- Chemical Sciences not elsewhere classified
- Information Systems not elsewhere classified
- novel compounds
- Collateral sensitivity
- artesunic acid molecules
- CEM
- Heterodimer Molecules
- Artesunic acid
- artesunic acid homodimer
- multidrug resistance
- artesunic acid
- reactive oxygen species
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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