textjournal article
Formal Nucleophilic Substitution of Bromocyclopropanes with Amides en route to Conformationally Constrained β-Amino Acid Derivatives
Abstract
A chemo- and diastereoselective protocol for the formal nucleophilic substitution of 2-bromocyclopropylcarboxamides with secondary amides is described. This method allows for convergent and highly selective synthesis of trans-β-aminocyclopropane carboxylic acid derivatives- Text
- Journal contribution
- Biochemistry
- Medicine
- Molecular Biology
- Evolutionary Biology
- Sociology
- Infectious Diseases
- Computational Biology
- Chemical Sciences not elsewhere classified
- derivative
- carboxylic
- convergent
- Bromocyclopropane
- Derivative
- acid
- synthesis
- diastereoselective protocol
- method
- Amide
- Formal Nucleophilic Substitution
- Conformationally
- amide
- nucleophilic substitution
- tran
- bromocyclopropylcarboxamide
- chemo
- Constrained
- Amino
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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