textjournal article
A Catalytic Homo-Nazarov Cyclization Protocol for the Synthesis of Heteroaromatic Ring-Fused Cyclohexanones
Abstract
A general protocol for the catalytic homo-Nazarov cyclization of cyclopropyl heteroaryl ketones has been developed, which employs indium triflate as the promoter. A range of heteroaromatic ring-fused cyclohexanones was synthesized in 56−91% yield using this protocol. An example of a tandem cyclopropanation/homo-Nazarov cyclization is also reported in which the one-pot yield is greater than the overall yield of the two individual steps- Text
- Journal contribution
- Biochemistry
- Genetics
- Biotechnology
- Developmental Biology
- Mental Health
- Environmental Sciences not elsewhere classified
- Biological Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Catalytic
- heteroaromatic
- Cyclization
- CyclohexanonesA
- cyclization
- cyclopropanation
- Synthesi
- tandem
- indium triflate
- Heteroaromatic
- promoter
- cyclohexanone
- cyclopropyl heteroaryl ketones
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Last time updated on 16/03/2018
This paper was published in The Francis Crick Institute.
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