Copper-Glucosamine Microcubes: Synthesis, Characterization, and C-Reactive Protein Detection

Abstract

Cubelike microstructures of glucosamine-functionalized copper (GlcN-CuMC’s) have been fabricated by the integration of injection pump and ultrasonochemistry. Although bulk microstructures and the nanostructure of metallic copper exhibit distinct applications, the amino sugar surface-functionalized copper is almost biocompatible and exhibits advanced features such as more crystallinity, high thermal stability, and electrochemical feasibility toward biomolecule (C-reactive protein, CRP) detection. An electrochemical test of this GlcN-CuMC’s was demonstrated by immobilization on a conventional gold-PCB (Au-PCB) electrode. The combination of a biointerface membrane, from glucosamine functionalization, and electroactive sites of metallic copper provides a very efficient electrochemical response against various concentration of CRP. A perfect scaling of steady-state currents with r2 values of 0.9862 (Ipa) and 0.9972 (Ipc) indicate the promise of this kind of biofunctionalized microstructure electrode for many surface and interface applications