Enantioselective Synthesis of 1-Aryl-tetrahydroisoquinolines through Iridium Catalyzed Asymmetric Hydrogenation
Abstract
Asymmetric hydrogenation of 1-aryl-3,4-dihydroisoquinolines using the [IrCODCl]<sub>2</sub>/(<i>R</i>)-3,5-diMe-Synphos catalyst is reported. Under mild reaction conditions, this atom-economical process provides easy access to a variety of enantioenriched 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives, which are important pharmacophores found in several pharmaceutical drug candidates, in high yields and enantiomeric excesses up to 99% after a single crystallization- Text
- Journal contribution
- Biophysics
- Biochemistry
- Molecular Biology
- Pharmacology
- Biotechnology
- Sociology
- Science Policy
- Virology
- Environmental Sciences not elsewhere classified
- Chemical Sciences not elsewhere classified
- Physical Sciences not elsewhere classified
- drug candidates
- reaction conditions
- enantiomeric excesses
- enantioenriched
- crystallization
- Iridium Catalyzed Asymmetric HydrogenationAsymmetric hydrogenation
- access
- derivative
- pharmacophore
- yield
- catalyst
- IrCODCl
- variety
- aryl
- Enantioselective Synthesis
Similar works
This paper was published in FigShare.
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