Importance of Secondary Interactions in Twisted Doubly Hydrogen Bonded Complexes
- Publication date
- 2012
- Publisher
Abstract
Three model hydrogen bond arrays that form complexes with large twist angles between their heterocyclic rings were synthesized differing only in the sequence of their hydrogen bond donors and acceptors. The complementary and self-complementary association of the arrays to form complexes was studied computationally and in solution. The analysis reveals the significant impact secondary interactions have on complex stability in such an arrangement despite the very different topology in comparison to typical planar arrays