textjournal article
Enantioselective Synthesis of Pladienolide B and Truncated Analogues as New Anticancer Agents
Abstract
An enantioselective synthesis of natural anticancer macrolide pladienolide B is described. The synthetic highlights include Sharpless asymmetric epoxidation, ring closing metathesis (RCM), Ireland–Claisen rearrangement, Shi epoxidation, and Pd-catalyzed Stille coupling as key steps. The synthetic route also allowed the synthesis of the truncated analogues (41a–d) of pladienolide B- Text
- Journal contribution
- Biophysics
- Biochemistry
- Cell Biology
- Molecular Biology
- Physiology
- Biotechnology
- Evolutionary Biology
- Sociology
- Marine Biology
- Infectious Diseases
- Plant Biology
- Chemical Sciences not elsewhere classified
- pladienolide B
- metathesi
- RCM
- Ireland
- Stille
- Truncated Analogues
- analogue
- Sharples
- Pladienolide B
- Shi epoxidation
- New Anticancer AgentsAn enantioselective synthesis
- Enantioselective Synthesis
- rearrangement
- anticancer macrolide pladienolide B
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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