Cyclic α,β-Tetrapeptoids: Sequence-Dependent Cyclization and Conformational Preference
Abstract
The presence of at least one <i>N</i>-Cα branched side chain is crucial for successful cyclization of α,β-tetrapeptoids. The <i>ctct</i> amide sequence revealed in the crystal structure of the 14-membered cyclotetrapeptoid <b>8</b> is also the most populated conformation in solution and is reminiscent of the predominant amide arrangement of the 12-membered cyclic tetrapeptides (CTPs)- Text
- Journal contribution
- Biophysics
- Biochemistry
- Cell Biology
- Computational Biology
- Chemical Sciences not elsewhere classified
- crystal structure
- Cyclization
- solution
- CTP
- amide arrangement
- side chain
- cyclization
- Tetrapeptoid
- cyclotetrapeptoid
- Cyclic
- tetrapeptide
- conformation
- Conformational PreferenceThe presence
- tetrapeptoid
- cyclic
- ctct amide sequence
- membered
Similar works
This paper was published in FigShare.
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