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Summary of the IC<sub>50</sub> (μM) values obtained for each antagonist drug with their respective Anticholinergic Cognitive Burden (ACB) and Serum Anticholinergic Activity (SAA) scores.

By Elizabeth K. Woehrling (312828), H. Rheinallt Parri (324046), Erin H. Y. Tse (698374), Eric J. Hill (312830), Ian D. Maidment (698375), G. Christopher Fox (698376) and Michael D. Coleman (312824)

Abstract

<p>Values represent the mean IC<sub>50</sub> values (μM) ± SEM (n = 3) for each drug.</p><p>Compared IC<sub>50</sub>s;</p><p>a dicycloverine vs amitriptyline,</p><p>b amitriptyline vs cyclobenzaprine and</p><p>c cyclobenzaprine vs cimetidine.</p><p>* P < 0.05,</p><p>** P < 0.01,</p><p>*** P < 0.001</p><p>Summary of the IC<sub>50</sub> (μM) values obtained for each antagonist drug with their respective Anticholinergic Cognitive Burden (ACB) and Serum Anticholinergic Activity (SAA) scores.</p

Topics: Biological Sciences, intracellular calcium, cholinergic response, amitriptyline, polypharmacy, quantitate increases, mAChR agonist oxotremorine, anticholinergic responses, ACB scores, anticholinergic effects, Vitro Model, anticholinergic risk, investigation, ACB scale, dicycloverine, drug use, drug scores, NT 2 astrocytes, cholinergic phenotypic markers, cyclobenzaprine, Muscarinic acetylcholine receptors, Human Neuronal, NT 2.N cells, Anticholinergic Properties, NT 2.N, NT 2 cell line, astrocytic cholinergic response, medication, neuron, Astrocytic Systems, cimetidine, combination, NT 2.N model, Anticholinergic Cognitive Burden
Year: 2015
DOI identifier: 10.1371/journal.pone.0118786.t002
OAI identifier: oai:figshare.com:article/1325505
Provided by: FigShare
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