Summary of the IC<sub>50</sub> (μM) values obtained for each antagonist drug with their respective Anticholinergic Cognitive Burden (ACB) and Serum Anticholinergic Activity (SAA) scores.
Abstract
<p>Values represent the mean IC<sub>50</sub> values (μM) ± SEM (n = 3) for each drug.</p><p>Compared IC<sub>50</sub>s;</p><p>a dicycloverine vs amitriptyline,</p><p>b amitriptyline vs cyclobenzaprine and</p><p>c cyclobenzaprine vs cimetidine.</p><p>* P < 0.05,</p><p>** P < 0.01,</p><p>*** P < 0.001</p><p>Summary of the IC<sub>50</sub> (μM) values obtained for each antagonist drug with their respective Anticholinergic Cognitive Burden (ACB) and Serum Anticholinergic Activity (SAA) scores.</p- Dataset
- Dataset
- Biological Sciences
- intracellular calcium
- cholinergic response
- amitriptyline
- polypharmacy
- quantitate increases
- mAChR agonist oxotremorine
- anticholinergic responses
- ACB scores
- anticholinergic effects
- Vitro Model
- anticholinergic risk
- investigation
- ACB scale
- dicycloverine
- drug use
- drug scores
- NT 2 astrocytes
- cholinergic phenotypic markers
- cyclobenzaprine
- Muscarinic acetylcholine receptors
- Human Neuronal
- NT 2.N cells
- Anticholinergic Properties
- NT 2.N
- NT 2 cell line
- astrocytic cholinergic response
- medication
- neuron
- Astrocytic Systems
- cimetidine
- combination
- NT 2.N model
- Anticholinergic Cognitive Burden
Similar works
This paper was published in FigShare.
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