Combination of Tempeh and Carrot Prevent Atherosclerosis Wistar Rat: Indicated by Increase of Hdl and Total Antioxidant, Decrease Ldl, F2-isoprostan, and Il-6

Coronary heart disease (CHD) is the leading cause of death, either in developed and developing countries. The disease is stimulated by the present of atherosclerosis. This study aims to investigate supplementation of combined tempeh M-2 and carrot to prevent atherosclerosis wistar rat by increases HDL and TAC, decreases LDL, F2-Isoprostan, and IL-6. This was a true experimental study with the factorial completely randomized post-test only control group design. variables such as KN (standard feeding / pellets (50 g / kg bw / day), KP: pig lubrication: pellets (1: 9) (50 g / kg bw / day), T : lubrication pig: pellets (1: 9) with tempeh M -2 (20 g / kg bw / day), W: pig lubrication: pellets (1: 9) with carrots (20 g / kg bw / day), and TW: pig lubrication: pellets (1: 9) with tempeh M-2 (20 g / kg bw / day), and carrots (20 g / kg bw / day). Dependent variables in this study are serum HDL,serum TAC, LDL serum, urine F2-Isoprostan, and plasma IL-6 (with Elisa Method). Data were analyzed using the F test (two-way ANOVA), followed by LSD test. Descriptive research was also conducted in this study in order to find out the change of aortic histopathologic. The highest average levels of HDL, TAC contained on TW, which respectively amounted 68.640 ± 0.50 mg / dl, 1.454 ± 0.01 nM / mL. It showed highly significant differences (p<0.01) in the various treatments. TW treatment showed highly significant interaction effect (p<0.01) were observed for all parameters except for HDL. Average levels of LDL, F2- Isoprostan, and IL-6 lowest in the treatment TW, which respectively amounted 20.718 ± 1.33 mg / dl, 0.720 ± 0.065 ng / dl, 35.328 ± 1.000 pg/dl, showed highly significant differences (p<0.01) in the various treatments. It can be concluded that supplementation with a combination of tempeh M-2 with carrots give the best effect, can increases HDL and TAC, and can decreases LDL, F2-Isoprostan, IL-6 significantly, and may change the hystopathology structure of aorta from endotel dysfunction to become normal

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Additive Combination Spaces

We introduce a class of metric spaces called $p$-additive combinations and show that for such spaces we may deduce information about their $p$-negative type behaviour by focusing on a relatively small collection of almost disjoint metric subspaces, which we call the components. In particular we deduce a formula for the $p$-negative type gap of the space in terms of the $p$-negative type gaps of the components, independent of how the components are arranged in the ambient space. This generalizes earlier work on metric trees by Doust and Weston. The results hold for semi-metric spaces as well, as the triangle inequality is not used.Comment: 17 page

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