Palladium-Catalyzed Synthesis of 5‑Iminopyrrolones through Isocyanide Double Insertion Reaction with Terminal Alkynes and Water
Abstract
With the combination of Pd(dppf)Cl2 and Cu(OAc)2, a variety of 5-iminopyrrolones were synthesized in moderate to good yields from terminal alkynes, isocyanide, and water via isocyanide double insertion and cycloaddition reaction. A plausible reaction mechanism for this process is depicted. Furthermore, selected compounds 3c, 3e, and 3h exhibited good activities against HepG2 (human liver cancer), NCI-H460 (human lung cancer), and SK-OV-3 (human ovarian cancer) cell lines with IC50 values in the range of 10.63–22.63 μmol L–1- Dataset
- Dataset
- Biochemistry
- Microbiology
- Molecular Biology
- Inorganic Chemistry
- Infectious Diseases
- Virology
- Chemical Sciences not elsewhere classified
- Isocyanide Double Insertion Reaction
- terminal alkynes
- SK-OV -3
- compounds 3 c
- 3 h
- HepG 2
- 3 e
- 5- iminopyrrolones
- Palladium-Catalyzed Synthesis
- IC 50 values
- isocyanide
- reaction mechanism
- cycloaddition reaction
- Terminal Alkynes
- cell lines
- NCI-H
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Last time updated on 12/02/2018
This paper was published in The Francis Crick Institute.
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