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Model-Based Bootstrapping on Classified Tensor Morphologies: Estimation of Uncertainty in Fibre Orientation and Probabilistic Tractography.

By Nagulan Ratnarajah, Andy Simmons, Oleg Davydov, Miguel Bertoni and Ali Hojjatoleslami

Abstract

In this study, fast and clinically feasible model-based bootstrapping algorithms using a geometrically constrained two-tensor diffusion model are employed for estimating uncertainty in fibre-orientation. Voxels are classified based on tensor morphologies before applying single or two-tensor model-based bootstrapping algorithms. Classification of tensor morphologies allows the tensor morphology to be considered when selecting the most appropriate bootstrap procedure. A constrained two-tensor model approach can greatly reduce data acquisition times and computational time for whole bootstrap data volume generation compared to other multi-fibre model techniques, facilitating widespread clinical use. For comparison, we propose a new repetition-bootstrap algorithm based on classified voxels and the constrained two-tensor model. White matter tractography with these bootstrapping algorithms is also developed to estimate the connection probabilities between brain regions, especially regions with complex fibre configurations. Experimental results on a hardware phantom and human brain data demonstrate the superior performance of our algorithms compared to conventional approaches

Topics: QA276, RZ, RC0321, QM
OAI identifier: oai:kar.kent.ac.uk:27767

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Citations

  1. (2006). B.: A statistical framework for the classification of tensor morphologies in diffusion tensor images. doi
  2. (2006). C.F.: Geometrically constrained two-tensor model for crossing tracts in DWI. doi
  3. (2003). P.J.: Parametric and non-parametric statistical analysis of DT-MRI data. doi
  4. (2002). Processing and visualization for diffusion tensor MRI. doi
  5. (2004). Q-ball imaging. doi
  6. (2006). R.G.: Comparison of bootstrap approaches for estimation of uncertainties of DTI parameters. doi
  7. (2007). Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. doi
  8. (2008). Using the wild bootstrap to quantify uncertainty in diffusion tensor imaging. doi
  9. (2002). V.: HARDI reveals intravoxel white matter fiber heterogeneity. doi
  10. (2008). W.L.: A note on the validity of statistical bootstrapping for estimating the uncertainty of tensor parameters in diffusion tensor images. doi

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