The cellular and synaptic architecture of the mechanosensory dorsal horn

The deep dorsal horn is a poorly characterized spinal cord region implicated in processing low-threshold mechanoreceptor (LTMR) information. We report an array of mouse genetic tools for defining neuronal components and functions of the dorsal horn LTMR-recipient zone (LTMR-RZ), a role for LTMR-RZ processing in tactile perception, and the basic logic of LTMR-RZ organization. We found an unexpectedly high degree of neuronal diversity in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiological, and synaptic properties. Remarkably, LTMRs form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to three LTMR classes, as well as spinal cord interneurons and corticospinal neurons. Thus, the LTMR-RZ is a somatosensory processing region endowed with a neuronal complexity that rivals the retina and functions to pattern the activity of ascending touch pathways that underlie tactile perception

EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy

Visual inspection of the EEG to determine the seizure onset zone (SOZ) in the context of the presurgical evaluation in epilepsy is time-consuming and often challenging or impossible. We offer an approach that uses EEG source imaging (ESI) in combination with functional connectivity analysis (FC) to localize the SOZ from ictal EEG. Ictal low-density-scalp EEG from 111 seizures in 27 patients who were rendered-seizure free after surgery was analyzed. For every seizure, ESI (LORETA) was applied on an artifact-free epoch selected around the seizure onset. Additionally, FC was applied on the reconstructed sources. We estimated the SOZ in two ways: (i)the source with highest power after ESI and (ii)the source with the most outgoing connections after ESI and FC. For both approaches, the distance between the estimated SOZ and the resected zone (RZ) of the patient were calculated. Using ESI alone, the SOZ was estimated inside the RZ in 31% of the seizures and within 10mm from the border of the RZ in 42%. For 18.5% of the patients, all seizures were estimated within 10mm of the RZ. Using ESI and FC, 72% of the seizures were estimated inside the RZ, and 94% within 10mm. For 85% of the patients, all seizures were estimated within 10mm of the RZ. FC provided a significant added value to ESI alone (p<0.001). ESI combined with subsequent FC is able to localize the SOZ in a non-invasive way with high accuracy. Therefore it could be a valuable tool in the presurgical evaluation of epilepsy

Discovery of the spectroscopic binary nature of three bright southern Cepheids

We present an analysis of spectroscopic radial velocity and photometric data of three bright Galactic Cepheids: LR Trianguli Australis (LR TrA), RZ Velorum (RZ Vel), and BG Velorum (BG Vel). Based on new radial velocity data, these Cepheids have been found to be members of spectroscopic binary systems. The ratio of the peak-to-peak radial velocity amplitude to photometric amplitude indicates the presence of a companion for LR TrA and BG Vel. IUE spectra indicate that the companions of RZ Vel and BG Vel cannot be hot stars. The analysis of all available photometric data revealed that the pulsation period of RZ Vel and BG Vel varies monotonically, due to stellar evolution. Moreover, the longest period Cepheid in this sample, RZ Vel, shows period fluctuations superimposed on the monotonic period increase. The light-time effect interpretation of the observed pattern needs long-term photometric monitoring of this Cepheid. The pulsation period of LR TrA has remained constant since the discovery of its brightness variation. Using statistical data, it is also shown that a large number of spectroscopic binaries still remain to be discovered among bright classical Cepheids.Comment: 9 pages, 14 figure

Mechanisms of carbon and nutrient release from acid impacted soils: Investigating competitive sorption and aggregate dispersion

Dissolved organic carbon (DOC) and associated nutrients are of critical importance to natural biogeochemical cycling. In recent decades, increased amounts of DOC have been observed in Northern Hemisphere surface waters recovering from acid deposition. Such increases in DOC can have significant implications for the productivity of surface waters, yet the mechanisms controlling DOC release are yet to be understood. As soils are one of the primary sources of DOC in surface waters, this study attempts to identify mechanisms controlling DOC release from soils in the context of changing deposition chemistry. Two experiments were designed to investigate two soil-related processes that can lead to the liberation of DOC and nutrients from riparian zone (RZ) and hillslope (HS) soils. First RZ soils collected from the Sleepers River USGS research station were used to conduct a flow through experiment using simulated sulfate impacted and non-impacted soils. In this experiment DOC solution was infiltrated to test the effect of competitive sorption between DOC and sulfate, however this effect could not be confirmed. In a second experiment, a batch approach was used to test the effect of pH and ionic strength (IS) on aggregate dispersion in both RZ and HS soils. Results reveal that IS, not pH, strongly controlled DOC release in all soils presumably by impacting soil aggregation. Release of DOC and P was similar for RZ vs. HS soils, however N release was significantly higher from RZ soils, indicating soil type and landscape position matter for nutrient release. Together these results indicate that changes in deposition IS more than pH or sulfate additions play a major role in the release of DOC and nutrients from soils at Sleepers River, likely due to the connection between IS and soil aggregate dispersion

The G-O Rule and Waldmeier Effect in the Variations of the Numbers of Large and Small Sunspot Groups

We have analysed the combined Greenwich and Solar Optical Observing Network (SOON) sunspot group data during the period of 1874-2011 and determined variations in the annual numbers (counts) of the small, large and big sunspot groups (these classifications are made on the basis of the maximum areas of the sunspot groups). We found that the amplitude of an even-numbered cycle of the number of large groups is smaller than that of its immediately following odd-numbered cycle. This is consistent with the well known Gnevyshev and Ohl rule or G-O rule of solar cycles, generally described by using the Zurich sunspot number (Rz). During cycles 12-21 the G-O rule holds good for the variation in the number of small groups also, but it is violated by cycle pair (22, 23) as in the case of Rz. This behaviour of the variations in the small groups is largely responsible for the anomalous behaviour of Rz in cycle pair (22, 23). It is also found that the amplitude of an odd-numbered cycle of the number of small groups is larger than that of its immediately following even-numbered cycle. This can be called as `reverse G-O rule'. In the case of the number of the big groups, both cycle pairs (12, 13) and (22, 23) violated the G-O rule. In many cycles the positions of the peaks of the small, large, and big groups are different and considerably differ with respect to the corresponding positions of the Rz peaks. In the case of cycle 23, the corresponding cycles of the small and large groups are largely symmetric/less asymmetric (Waldmeier effect is weak/absent) with their maxima taking place two years later than that of Rz. The corresponding cycle of the big groups is more asymmetric (strong Waldmeier effect) with its maximum epoch taking place at the same time as that of Rz.Comment: 13 pages, 5 figures, 1 table, accepted by Solar Physic

An extensive photometric study of the Blazhko RR Lyrae star RZ Lyr

The analysis of recent, extended multicolour CCD and archive photoelectric, photographic and visual observations has revealed several important properties of RZ Lyr, an RRab-type variable exhibiting large-amplitude Blazhko modulation. On the time-base of \sim110 yr, a strict anticorrelation between the pulsation and modulation period changes is established. The light curve of RZ Lyr shows a remarkable bump on the descending branch in the small-amplitude phase of the modulation, similarly to the light curves of bump Cepheids. We speculate that the stellar structure temporally suits a 4:1 resonance between the periods of the fundamental and one of the higher-order radial modes in this modulation phase. The light-curve variation of RZ Lyr can be correctly fitted with a two-modulation-component solution; the 121 d period of the main modulation is nearly but not exactly four times longer than the period of the secondary modulation component. Using the inverse photometric method, the variations in the pulsation-averaged values of the physical parameters in different phases of both modulation components are determined.Comment: 15 pages, 14 figures, 8 tables. Published in MNRAS, 2012. [v3]: Only change: title correcte

A closer look at arrested spinodal decomposition in protein solutions

Concentrated aqueous solutions of the protein lysozyme undergo a liquid solid transition upon a temperature quench into the unstable spinodal region below a characteristic arrest temperature of Tf=15C. We use video microscopy and ultra-small angle light scattering in order to investigate the arrested structures as a function of initial concentration, quench temperature and rate of the temperature quench. We find that the solid-like samples show all the features of a bicontinuous network that is formed through an arrested spinodal decomposition process. We determine the correlation length Xi and demonstrate that Xi exhibits a temperature dependence that closely follows the critical scaling expected for density fluctuations during the early stages of spinodal decomposition. These findings are in agreement with an arrest scenario based on a state diagram where the arrest or gel line extends far into the unstable region below the spinodal line. Arrest then occurs when during the early stage of spinodal decomposition the volume fraction phi2 of the dense phase intersects the dynamical arrest threshold phi2Glass, upon which phase separation gets pinned into a space-spanning gel network with a characteristic length Xi

Long-time dynamics of Rouse-Zimm polymers in dilute solutions with hydrodynamic memory

The dynamics of flexible polymers in dilute solutions is studied taking into account the hydrodynamic memory, as a consequence of fluid inertia. As distinct from the Rouse-Zimm (RZ) theory, the Boussinesq friction force acts on the monomers (beads) instead of the Stokes force, and the motion of the solvent is governed by the nonstationary Navier-Stokes equations. The obtained generalized RZ equation is solved approximately. It is shown that the time correlation functions describing the polymer motion essentially differ from those in the RZ model. The mean-square displacement (MSD) of the polymer coil is at short times \~ t^2 (instead of ~ t). At long times the MSD contains additional (to the Einstein term) contributions, the leading of which is ~ t^(1/2). The relaxation of the internal normal modes of the polymer differs from the traditional exponential decay. It is displayed in the long-time tails of their correlation functions, the longest-lived being ~ t^(-3/2) in the Rouse limit and t^(-5/2) in the Zimm case, when the hydrodynamic interaction is strong. It is discussed that the found peculiarities, in particular an effectively slower diffusion of the polymer coil, should be observable in dynamic scattering experiments.Comment: 6 page

A semiclassical Egorov theorem and quantum ergodicity for matrix valued operators

We study the semiclassical time evolution of observables given by matrix valued pseudodifferential operators and construct a decomposition of the Hilbert space L^2(\rz^d)\otimes\kz^n into a finite number of almost invariant subspaces. For a certain class of observables, that is preserved by the time evolution, we prove an Egorov theorem. We then associate with each almost invariant subspace of L^2(\rz^d)\otimes\kz^n a classical system on a product phase space \TRd\times\cO, where \cO is a compact symplectic manifold on which the classical counterpart of the matrix degrees of freedom is represented. For the projections of eigenvectors of the quantum Hamiltonian to the almost invariant subspaces we finally prove quantum ergodicity to hold, if the associated classical systems are ergodic