Peningkatan Ekspresi Transforming Growth Factor Beta 1 (TGF β1) Pada Luka Diabetes Melitus Melalui Balutan Modern

Abstract

Reduction of expression of transforming growth factor beta 1 in diabetic ulcers affects overall wound healing. This study tried to draw a comparison of transforming growth factor beta 1 level between modern dressing and conventional dressing in diabetic foot ulcer. This study applied a quasi-experimental pretest-posttest design and a consecutive sampling method of data collection. Immunohistochemical analysis of transforming growth factor beta 1 level was measured on the day 0 (pretest) and the day 4 (posttest). In this study, the modern dressing application improves transforming growth factor beta 1 level. Meanwhile, the conventional dressing application decreases transforming growth factor beta 1 level. Thus, it can be concluded that the modern dressing application can increase transforming growth factor beta 1 level