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Click, Substitute and Fluoresce: Synthesis and Applications of 2,6-Di-(1,2,3-triazolyl)-purine Nucleosides

By Irina Novosjolova, Armands Kovaļovs, Inga Bižāne, Ērika Bizdēna and Māris Turks


A novel class of ditriazolylpurine nucleosides were ob-tained from 2,6-diazido precursors via copper catalyzed azide-alkyne cycloaddition. These intermediates ap-peared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-substituted analogs with triazolyl moiety at C(2)-position. The latter products exhibit interesting fluorescence properties

Topics: ditriazolylpurine nucleosides, 1, 3-dipolar cycloaddition reaction, fluorescence
Publisher: IS3NA
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