Click, Substitute and Fluoresce: Synthesis and Applications of 2,6-Di-(1,2,3-triazolyl)-purine Nucleosides
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- IS3NA
Abstract
A novel class of ditriazolylpurine nucleosides were ob-tained from 2,6-diazido precursors via copper catalyzed azide-alkyne cycloaddition. These intermediates ap-peared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-substituted analogs with triazolyl moiety at C(2)-position. The latter products exhibit interesting fluorescence properties