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Tin(IV)-functionalised polymer supports; Non-toxic and practical reagents for regioselective acetylation of sucrose

By Wallace M. Macindoe, Andrew Williams and Riaz Khan


Polymer-supported butyltin(IV) reagents have been surveyed for regioselectivity in acetylation of sucrose. Polymer-supported butyltin(IV) dichloride 8 catalysed the acetylation of sucrose to give a 59% yield of 6-O-acetyl sucrose 3, the precursor of sucralose. The yield is close to that of a previously reported process involving dibutyltin(IV) oxide (Bu(2)SnO). The spent polymeric resin could readily be regenerated and can be subsequently used in further synthetic reactions

Topics: QP517, QD, QP506
Year: 1996
DOI identifier: 10.1016/0008-6215(95)00392-4
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