Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*)

Hohmann, Claudia; Schneider, Kathrin; Bruntner, Christina; Irran, Elisabeth; Nicholson, Graeme; Bull, Alan T.; Jones, Amanda L.; Brown, Roselyn; Stach, James E.M.; Goodfellow, Michael; Beil, Winfried; Kramer, Marco; Imhoff, Johannes F.; Sussmuth, Roderich D.; Fiedler, Hans-Peter

oai:kar.kent.ac.uk:17850

Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937(*)

Authors: Claudia Hohmann
Kathrin Schneider
Christina Bruntner
Elisabeth Irran
Graeme Nicholson
Alan T. Bull
Amanda L. Jones
Roselyn Brown
James E.M. Stach
Michael Goodfellow
Winfried Beil
Marco Kramer
Johannes F. Imhoff
Roderich D. Sussmuth
Hans-Peter Fiedler
Publication date: 23 January 2009
Publisher: Japan Antibiotics Research Assoc, 2 20 8 Kamiosaki Shinagawa Ku, Tokyo, 141, Japan
Doi

Abstract

Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.The Journal of Antibiotics (2009) 62, 99-104; doi:10.1038/ja.2008.24; published online 23 January 2009

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