Human rights health care measures reporting physical fitness test for ages 6 to 17 with 10-year follow-up（6歳から17歳児の、10年をおいた体力テストの調査から、健康に関わる人権についての報告）

信州大学Shinshu University博士（医学）次の雑誌に発表。 /International Journal of Human Rights in Healthcare 18(1) :92-106(2025); doi:10.1108/IJHRH-12-2023-0092 © Satomi Fujimori, Kazuki Ashida, Noriaki Watanabe, Tomoyuki Nishino, Fumihito Sasamori, Masao Okuhara, Hisaaki Tabuchi and Koji Terasawa. Published by Emerald Publishing Limited. This article is published under the Creative Commons Attribution (CC BY 4.0) licence.doctoral thesi

PI3K pathway activation in severe asthma is linked to steroid insensitivity and adverse outcomes

Background: Patients with severe asthma may demonstrate reduced sensitivity to steroid treatment. However, the implications of this reduced responsiveness for clinical outcomes and the underlying mechanisms remain unclear. Objective: The aim of this study was to investigate whether steroid sensitivity in patients with asthma is related to severity and clinical outcomes and to elucidate the role of inflammatory pathways in reducing steroid sensitivity. Methods: This observational study of 169 asthma patients, with 161 followed for 1 year, involved isolation of peripheral blood mononuclear cells. These cells were treated with dexamethasone, and the mRNA expression of FKBP5, which is a marker of steroid sensitivity, was measured. To explore the mechanism underlying the reduced steroid sensitivity, cells were exposed to PI3K and MAPK inhibitors in combination with dexamethasone. Results: A total of 53 patients diagnosed with severe asthma exhibited markedly diminished sensitivity to steroids compared with those with nonsevere asthma. Reduced steroid sensitivity has emerged as a critical risk factor for failure to experience clinical remission and exacerbation. This relationship between reduced steroid sensitivity and disease severity and adverse outcomes was confirmed at the 1-year follow-up. Mechanistic investigations revealed that the degree of recovery from steroid sensitivity after PI3Kδ/γ inhibitor treatment was significantly greater in patients with severe asthma than in those with nonsevere asthma, a finding confirmed at the 1-year follow-up. Conclusions: Patients with severe asthma demonstrate reduced steroid sensitivity, which results in unfavorable clinical outcomes. Conversely, inhibition of the PI3K pathway significantly improves steroid sensitivity.journal articl

令和6年度AFC用地使用一覧

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生合成コンポーネントに着目した組換え枯草菌を用いたバイオポリマー”ポリグルタミン酸”の生産【本文の要約】

信州大学Shinshu University博士（医工学）この博士論文は、論文データとして次の学術雑誌論文を一部に使用しています。図表については本学位論文用に作成し収載しています。 || AMB Express 8(1) :110(2018); doi:10.1186/s13568-018-0636-x © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.|| Bioscience, Biotechnology, and Biochemistry 88(10) :1217-1224(2024); doi:10.1093/bbb/zbae093 © The Author(s) 2024. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model.|| Bioscience, Biotechnology, and Biochemistry :zbaf120(2025); doi:10.1093/bbb/zbaf120 © The Author(s) 2025. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model.doctoral thesi

小中学校におけるメイカースペースの整備と利用目的の探索的検討

departmental bulletin pape

教科横断的な理科の授業の実践的検討―他教科の資質・能力を活用する要因と深い興味の変容に着目して―

departmental bulletin pape

Learning to “Read” With Creative Activities: Nurturing “Creativity” and “Criticality” Through Gongitsune (in 4th Grade of Elementary School)

departmental bulletin pape

信州大学附属図書館職員発表等一覧(2024.1.1-2024.12.31)

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小・中学校の通知表における成績の付け方及び所見記述の現状分析－初任者へのインタビュー調査をもとに－

本研究では、初任者へのインタビュー調査をもとに、所属校の通知表テンプレートの分析も交え、小・中学校の通知表における成績の付け方や所見記述の現状をまとめた。調査の結果、現行学習指導要領に基づき通知表を改訂し、教科の評価は３観点を基準とし、テスト結果だけでなく、日頃の学習過程も考慮して成績を付けている状況が伺えた。また、所見の作成には多大な労力がかかっているが、同僚から提供された文例を参考にしたり、自身の日々の記録や児童生徒の学習カードをもとにしたりして作成していた。作成にはExcelや統合型校務支援システムを使用していたが、データの一元管理は十分に行われていなかった。課題として、通知表作成の意図や趣旨の十分な理解、一人一人の児童生徒の記録の不十分さ、主観的な評価への不安、時間的負担が挙げられており、通知表作成において、改善すべき点が明らかになった。departmental bulletin pape

Teacher Awareness and the Challenges of Implementing Financial Consumer Education: Results and Analysis of a Survey of Teachers on Financial Consumer Education

departmental bulletin pape