Smart Doorknob Cleanser

During the sensitive times of a global pandemic, we have learned over time that diseases such as Covid-19 can live on surfaces for days. The senior project idea is to design, construct, and implement a prototype able to disinfect doorknobs after the surface has been encountered or used. To fight against harmful bacteria's, there is a need to attack one of the main sources where bacteria is being transmitted the most. In fact, scientists have determined that on average a minimum of at least five different colonies of bacteria are on a single doorknob at any given time. The purpose of the device is to spray a mist of alcoholic solution onto the doorknob surface allowing the solution to disinfect the main surface area. The main objective of this project is to keep the environment clean and reduce the spread of viruses and germs. In addition, the device is set to follow constraints that provide the opportunity for the device to be cost effective, efficient, and adjustable. As a result, these constraints will improve productivity, safety, and be more user friendly to consumers. By applying previous engineering coursework, the plan is to incorporate notes from classes such as fluid mechanics, machine design, network analysis, and computer aided design to fulfill the needs of the project. The device is planned to include a fluid mechanism that will be used to spray the alcoholic solution after the doorknob has sensed motion within a specific time interval. Also, referring to the constraints of the project implementing a refillable cartridge with automated fill level notification would be ideal in making sure the alcohol solution can be easily replaced when the cartridge has reached a level of emptiness. These fill levels will be indicated in a form of a display screen communicating to the consumer that the cartridge is empty, half empty, or full and ready for use. This ensures the device is indeed performing and communicating whether the solution needs to be refilled. Overall, the goal is to create a sanitized and trusted environment for consumers when utilizing the smart doorknob sensor. This device would be used as a combat against diseases being transmitted in public areas such as office buildings, schools, and public bathrooms

Effects of Leukocyte-Platelet Rich Fibrin and Nanoporous Scaffolds on Cell Proliferation and Cell Migration

In regenerative medicine, repair and regeneration of defects and damage in both soft and hard tissues still remain a challenge. Hence, better bioengineering strategies and biomaterials are needed. Autologous platelet concentrates are potential tools from which regenerative medicine can benefit. The Leukocyte Platelet Rich Fibrin (L-PRF) is a subfamily of the PRF concentrates that has been in the spotlight because of its simplicity. The presence in its enriched solid three-dimensional fibrin matrix of leukocytes, proteins, cytokines, growth factors, and stem cells give this biomaterial angiogenic, osteogenic, hemostatic, anti-inflammatory, antimicrobial, analgesic, and wound healing properties. Polymeric substances, such as PLGA have demonstrated potential to operate as a scaffold for bone volume augmentation. The ability to tailor the material's properties at the molecular level is one the benefits that allow these materials to be used as proper scaffolds for cells

IMAGE PROCESSING TECHNIQUES FOR DETECTING PNEUMONIA

In 2019 alone, Pneumonia was the cause of 2.49 Million deaths around the world. If we count the deaths due to COVID-19 since 2020 for all-cause pneumonia, Pneumonia would surpass all other infectious killers. While traditionally speaking, Pneumonia is considered as a lung disease, acute pneumonia has important effects on the cardiovascular system at all severities of infection. It is also a leading cause of worsening cardiovascular risk and results have shown that about a quarter of adults admitted to hospital with pneumonia develop a major acute cardiac complication during their treatment and an increase of 60% in short-term mortality. As it has always been one of the major infectious diseases resulting in millions of deaths of children as well as elderly population, there is a strong interest and research to find an early diagnosis of pneumonia with easily accessible technology

Scalability: One Of The Main Challenges Of a Blockchain

Blockchain is a distributed peer-to-peer network, which is connected using nodes throughout the globe. Each node has a transactions ledge, which maintains the whole record of transactions. In blockchain data is stored electronically in digital format which is amazing. A database ordinarily stores its data in tables, whereas in blockchain data is stored in chunks as referred by its name blocks. They are better for maintaining secure and decentralized transactions because in blockchain blocks are connected as a single network. In blockchain transactions can be done between two parties without the involvement of a third party, which means one can maintain their own money without depending on others. Bitcoin is one of application of blockchain, where bitcoin goes through many confirmations on the blockchain before it is cleared because the unconfirmed transaction can be reversed or crypto-currency can be spend twice. Average confirmation time on bitcoin network for a BTC payment is about 10 minutes, which seriously needs be scaled for real-time applications

ORE'S Lock

Aiming to change the way people use locks. ORE offers a completely different approach from standard locks today. ORE lock uses Virtual keys which are a secure, encrypted WIFI Key that enables you to lock and unlock your door via your phone. virtual keys can be shared with anyone that you want. This all works through our app, making for a seamless experience

Novel Therapeutic Inhibitors Having Sugar Moiety Targeting HER2/EGFR as Anticancer Agent

Several effective small-molecule inhibitors of HER2 or EGFR have been developed to treat metastatic cancer, and some of those drugs are dual HER2/EGFR inhibitors. To investigate the mechanism of the dual inhibition of the receptor tyrosine kinases HER2 and EGFR1, we carried out virtual screening for benzimidazole derivatives having sugar moiety. Based upon virtual screening and HER2/EGR1 assays data simulation, we confirmed and chosen the benzimidazole skeleton which NO2 functional groups as a key skeleton for the dual inhibition towards HER2/EGFR1 (8.81 µM, Figure 6) to design novel tyrosine kinases inhibitors. After selection of the core skeleton, we designed our novel inhibitors, targeting both HER2/ EGFR1 and having a benzimidazole skeleton including a sugar moiety as aiming to balance their hydrophilic and hydrophobic properties and to increase cell penetration including the pharmacokinetics properties. We are investigating the synthesis of target agent (T-1) and biological properties of these agents against cancer cell line

Molecular Dynamics Simulation of [2] Rotaxane Switch

Although the development of molecular electronic devices faces challenges, researchers still have confidence in molecular electronics. Nowadays, researchers have revealed a series of electrical, optical, chemical and chiral properties of numerous small molecules for replacing the existing electronic components with the new features. Due to the switching ability that can be driven electrically, the voltage-driven bistable [2]rotaxane molecules are powerful candidates. In this poster, we proved the characteristics of the voltage-driven [2]rotaxane as a molecular electronic switch by using Nanoscale Molecular Dynamics (NAMD) and Visual Molecular Dynamics (VMD) simulation tools

Foreign Currency Reserve & Function United States, Russia, and China

In October 1959, a Yale professor sat in front of Congress’ Joint Economic Committee and calmly announced that the Bretton Woods system was doomed. The dollar could not survive as the world’s reserve currency without requiring the US to run ever-growing deficits. This dismal scientist was Robert Triffin, and he was right. The Bretton Woods system collapsed in 1971, and today the dollar’s role as the reserve currency has the US running the largest current deficit in the world

The Effect of Economic Freedom on Economic Growth: A Reexamination

Numerous studies have attempted to uncover the nature of the relationship between economic growth and various measures of legal, financial and political institutions. One of the fundamental questions is this: does economic freedom lead to economic growth? Skepticism about the economic performance of democratic institutions is as old as democracy itself. One school of thought argues that democracy can be a constraint on economic growth. According to this school, more political rights do not translate into growth (Robert Barro, 1997). The evidence from the literature has been mixed. A review paper by Gering et al. (2005) concludes that the net effect of democracy on growth performance cross-nationally over the last five decades is negative or null. A recent paper by Acemoglu et al. (2019) provides evidence that democracy has a positive effect on GDP per capita. Its baseline results show that democratizations increase GDP per captia by about 20% in the long run. Brik et al (2020) show that increases, but not the levels, in economic freedom are related to economic growth. Empirical studies on the effect of political institutions on GDP face several challenges such as the issue of measurement error and missing variables. This study contributes to the literature by using most recent data to examine the relationship between economic growth and economic freedom. It shows that improvement in economic freedom leads to positive economic growth

Impact of Pandemic on the U.S. Economy

As the Covid-19 Global Pandemic wreaked havoc in the health systems of the world especially in the developed nations of the world, the economy has suffered an equivalent damage if not more. With the economy going through the third wave of the pandemic, little is known about what the pandemic has in store for the future. Hence, in this paper we strive to analyses the impact of the COVID-19 pandemic on the economic aspects of the nation and the financial markets by analyzing various elements such as unemployment, tourism activities, monetary policy, and other policy responses. It is concluded that all the activities have had a severe negative impact on the economy and have led to greater uncertainty in the nation during the first two waves of the pandemic