Major approaches and scientific relevance of virtual surgery in implant dentistry: a systematic review

Introduction: Dental implant procedures have increased worldwide, reaching approximately one million dental implants per year the optimization of faster and more accurate techniques by dentists and postoperative surgeons with better results and quality of life stimulated the development of numerous software and hardware for performing computer-guided surgeries, the so-called Guided Surgeries (GS). Objective: The present study carried out a systematic review to highlight the optimization of the safety and effectiveness of digital dental implants. Methods: The rules of the Systematic Review-PRISMA Platform were followed. The research was carried out from June to July 2024 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 112 articles were found. A total of 42 articles were fully evaluated and 14 were included in the systematic review. A total of 32 studies were excluded because they did not meet the GRADE criteria, and 20 studies were excluded because they had a high risk of bias. Preoperative virtual planning and reconstruction of the mandible guided by dental implants through preoperative designs provide high success rates for the implant and dental rehabilitation, benefiting also prosthetic restorations supported by fixed implants. Still, the concept of using personalized implants with the help of 3D virtual treatment planning, stereolithographic models, and computer-assisted design greatly improves mandibular restoration and helps to obtain a good facial profile, and aesthetic and dental rehabilitation, avoiding complications with autologous grafts

Major considerations and findings of clinical studies on zygomatic implant placement in older patients with severe maxillary atrophy: a systematic review

Introduction: Zygomatic implant (ZI) rehabilitation of edentulous patients with maxillary atrophy is an approach that has been used with well-standardized procedures and considerable survival. Objective: The aim was to address and describe the main considerations and findings of clinical studies on the placement of zygomatic implants in elderly patients with severe maxillary atrophy. Methods: The present study followed a concise systematic review model (PRISMA rules). The search was carried out in the PubMed, Embase, Ovid, Cochrane Library, Web of Science, and Scopus databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 116 articles were found. In total, 41 articles were fully evaluated and 25 were included and evaluated in this study. Of the initial total of articles, 28 articles were excluded because they did not meet the GRADE and AMSTAR-2 classification, and 12 were excluded because they presented a risk of bias that could compromise the credibility of the studies. The symmetric funnel plot does not suggest a risk of bias. According to the GRADE instrument, most studies presented homogeneity in their results, with X2=92.1%>50%. It was concluded that the use of zygomatic implants is an alternative procedure, making implant rehabilitation of extensively atrophic maxillas possible when conventional procedures are not possible. Several anatomical and procedural factors, such as sinus conformation and sinus mucosa thickness, may influence the overall success of zygomatic implant rehabilitation and predispose to a higher occurrence of complications. Furthermore, dynamic navigation technology had better predictability in terms of precision and accuracy

Clinical outcomes of the importance of minimally traumatic tooth extraction for dental implant and aesthetic: a systematic review

Introduction: In the context of tooth extraction, this clinical practice is common for dentists, with the main causes of caries, periodontal disease, and coronal-radicular fractures. The choice for rehabilitation with implants has been growing, and to be carried out, it needs alveolar bone preservation at the implant site and adequate gingival contour, especially in aesthetic regions. However, the new techniques and instruments for minimally traumatic extraction still need to be analyzed, as little research has evaluated the success rate and limitations of these devices. Objective: It was developed a systematic review to highlight the importance of minimally traumatic tooth extraction for dental implants and aesthetics. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from November 2024 to January 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 130 articles were found, 32 articles were evaluated in full and 25 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 21 studies with a high risk of bias and 32 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=81.6%>50%. It was concluded that the use of precise and minimally traumatic techniques enabled satisfactory and functional aesthetic results, as well as improving the patient's aesthetics and self-esteem. The immediate implant placement procedure after tooth extraction preserves bone height and thickness, reduces treatment time and cost, in addition to maintaining the gingival architecture, being important for the aesthetic success of future prosthetic rehabilitation. Also, it presents success rates comparable to implants in fully healed edges, the extraction must be done in a minimally traumatic way, to preserve the maximum bone tissue. The horizontal defects present after the installation of the immediate implant, if they are less than or equal to 3mm, will heal with complete bone filling. However, if they are larger than 3mm, bone graft material and/or membrane should be used so that there is bone healing

Major evidence from the crosstalk between nutrology and lifestyle for healthy longevity: a systematic review

Introduction: Life expectancy worldwide has increased significantly. Centenarians represent a successful aging phenomenon. Genetic, environmental, and lifestyle factors can determine the life expectancy of humans. Certain healthy foods are associated with longer telomere lengths. Objective: It was to present the main evidence of the crosstalk between nutrition, lifestyle, and healthy longevity to promote health and improve quality of life in aging. Methods: The PRISMA Platform systematic review rules were followed. The research was carried out from May to July 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 133 articles were found. A total of 33 articles were evaluated in full and 31 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 27 studies with a high risk of bias and 23 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=72.5%>50%. It was concluded that many metabolic or chronic diseases have been implicated in poor diet and lifestyle. Improving diet quality is associated with reduced all-cause mortality, considering that multivitamin and multimineral supplements can improve life expectancy, such as nutrients such as melatonin and coenzyme Q10 and micronutrients. The synergistic relationship of nutrients to influence physiological and cognitive function. Low concentrations of vitamin D have been linked to accelerated decline in cognition across ethnicities. N-acetylcysteine can help treat schizophrenia, bipolar disorder, and depression by decreasing oxidative stress and reducing glutamatergic dysfunction, and has broader preclinical effects on mitochondria, apoptosis, neurogenesis, and telomere lengthening. A healthy (low-sugar) plant-based diet with a reduced intake of energy-dense meat and processed meat enables healthy longevity. Several mechanisms are involved in the aging process, highlighting AMPK (AMP-activated protein kinase), SIRT1 (sirtuin), mTOR (mammalian target of rapamycin), and insulin/IGF-1 (insulin-like growth factor-1), autophagy impaired, changes in epigenetics, chronic low-grade inflammation, and cellular changes, senescence (inflammation), oxidative stress and telomere shortening

Major considerations and outcomes of the periodontal diseases and infective endocarditis: a concise systematic review

Introduction: Infective endocarditis (IE) is a bacterial infection of the heart's inner lining. Substantial evidence supports a link between oral health and IE, with the oral microbiome impacting multiple aspects of IE, including pathogenesis, diagnosis, treatment, and mortality rates. Objective: It was to conduct a concise systematic review of the major guidelines by the American Heart Association and work related to bacterial resistance in periodontal diseases and infective endocarditis. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from February to March 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 105 articles were found, and 27 articles were evaluated in full and 14 were included and developed in the present concise systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 28 studies with a high risk of bias and 20 studies that did not meet GRADE and AMSTAR-2. Most studies showed homogeneity in their results, with X2=74.7%>50%. It was concluded that there is a significant association between periodontitis and increased cardiovascular risk, promoting integrated health approaches. Infective endocarditis, although relatively uncommon, is a disease that causes substantial morbidity and mortality. Although advances in diagnosis and treatment have improved antimicrobials, prevention is still an important factor. Protocols for the use of prophylactic antibiotics have been used in medical and dental procedures likely to generate the development of the disease in high-risk patients. Thus, the use of antibiotic prophylaxis is associated with a reduced risk of infective endocarditis after invasive dental procedures

Evaluation of the response to photobiomodulation and magnetotherapy in osteonecrosis of the jaws induced by the use of bisphosphonates: a systematic review

Introduction: Bisphosphonates are drugs that act on bone metabolism, inhibiting calcium precipitation and bone resorption. When used for long periods to control osteoporosis, these drugs can cause adverse effects, such as osteonecrosis of the jaws (Bisphosphonate-Related Osteonecrosis of the Jaws - BRONJ), which is more frequent in 8% to 12% of patients when administered intravenously. However, it should be noted that complications, when they occur, are very severe and mutilating, greatly impairing the quality of life of these patients. Energy-based devices (EBD), described in the biophotonic literature, reveal effective anti-inflammatory, analgesic, neoangiogenic, and reparative action. Objective: It was conducted a systematic review to present the main clinical considerations and consequences of the use of bisphosphonates in the occurrence of osteonecrosis of the jaw, as well as to discuss the treatments of photobiomodulation and magnetotherapy. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from November 2024 to January 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 118 articles were found, 30 articles were evaluated in full and 12 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 31 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=88.5%>50%. It is concluded that with the increasing use of bisphosphonates against osteoporosis especially in cases of postmenopausal women with osteopenia, a proportionally higher incidence of the main adverse effect of these drugs in the maxillomandibular region, osteonecrosis of the jaw, has emerged. The "gold standard" therapy of choice proposed for this disease is surgical treatment. Complications, when present, are very severe and mutilating, greatly impairing the quality of life of these patients. Morbidities include extensive resections, secondary infections, lack of tissue for primary closure, dehiscence, and fistulas, which can evolve into multilateral wounds with serious consequences, such as sepsis. In this regard, photobiomodulation therapy and magnetotherapy demonstrated safety and efficacy in the treatment of bisphosphonate-related osteonecrosis of the jaw, through reduction of inflammatory signs, faster healing, and reduction of postoperative morbidity. Thus, it was demonstrated that only four applications of low-intensity laser and magnetotherapy were sufficient to reduce the inflammatory process in the surgical wound, stimulate the tissue repair process, and provide postoperative analgesia

Major characteristics of the dental pulp regeneration process under the stimulation of biomaterials, bioactive Compounds, cells, and molecules: a systematic review

Introduction: Dental pulp regeneration is a challenging process that requires sophisticated cellular and molecular mechanisms, as well as biomaterials, to support the pulp's diverse functions, including immune defense, sensory perception, vascularization, and reparative dentinogenesis. Dental pulp contains stem cells with characteristics similar to mesenchymal stem cells. Dental pulp-derived stem cells (DPSC) can regenerate a variety of tissues. Objective: This was a systematic review to elucidate the main characteristics of the dental pulp regeneration process under the stimulation of biomaterials, bioactive compounds, cells, and molecules, as well as to present the main clinical outcomes. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from May to June 2025 in Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 114 articles were found, and 24 articles were evaluated in full, and 22 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 25 studies with a high risk of bias and 32 studies that did not meet GRADE and AMSTAR-2. According to the GRADE instrument, most studies presented homogeneity in their results, with X2=91.7%>50%. It was concluded that dental pulp stem cells can promote nerve regeneration through mitochondrial transfer, presenting a promising strategy for improving stem cell-based therapies for nerve injuries. Furthermore, hydrogels specifically developed to regulate the JAG1/Notch signaling pathway have demonstrated potential for pulp tissue regeneration. Mineral Trioxide Aggregate (MTA) is an excellent marginal sealer that prevents bacterial migration into the canal. It is a biocompatible cement that induces dentinogenesis, cementogenesis, and osteogenesis. Calcium hydroxide remains a standard material for use in pulp capping due to its bactericidal effect

Major clinical outcomes of parendodontic surgery in patients with chronic non-communicable diseases: a systematic review

Introduction: In the context of chronic diseases and the challenges of endodontic surgery, there are some cases where, even after the correct use of endodontic resources, treatment fails, and the endodontist's first option is to perform retreatment. Objective: It was to develop a systematic review to list the main approaches and clinical challenges of endodontic surgery. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from November to December 2024 in Scopus, Embase, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 230 articles were found, and 37 articles were evaluated in full and 26 were included and developed in this systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 33 studies with a high risk of bias and 53 studies that did not meet GRADE and AMSTAR-2. It was concluded that periodontal surgery is a viable, safe, and effective alternative for patients with chronic diseases. Proper planning, where indications are taken into account, is directly linked to the success rate of clinical cases. Apicoectomy combined with apical curettage significantly improves the prognosis of the case. Mineral Trioxide Aggregate is the material most often described as having the highest positivity for retrofilling. The best way to perform a retroperitoneal preparation is with the aid of ultrasound. The laser is a technological advance in the decontamination of the apical region, and the microscope is a magnificent aid in visualizing the operated area, increasing the rate of surgical success. Through a correct diagnosis and the technique chosen to perform the surgical treatment, it is possible to have a successful surgery and an excellent prognosis. Thus, the success rates of endodontic surgeries depend on the indication of the surgical modality, retro-obturator materials, previous quality of the root canal filling, treatment of the surgical pocket, execution of the surgical technique, and periodontal conditions

Best practices in palliative dentistry to improve patients’ quality of life: a systematic review

Introduction: Palliative Care (PC) is an approach that promotes the quality of life of patients and their families who face life-threatening illnesses through the prevention and relief of suffering. Oral care plays an important role in patient comfort and effective palliative care strategies for relieving oral complications. Objective: This study aimed to analyze the main considerations of palliative care that should be applied by dentists to better understand the best practices of palliative dentistry to improve the quality of life of patients, as well as mitigate the increase in complications after the diagnosis of a disease. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from November 2024 to January 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument, and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 177 articles were found, and 50 articles were evaluated in full, and 18 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 24 studies with a high risk of bias and 27 that did not meet the GRADE and AMSTAR-2 criteria. According to the GRADE instrument, most studies presented homogeneity in their results, with X2=85.7%>50%. It was concluded that the understanding of palliative care has changed. Previously, it was defined as an approach to the patient when there was nothing else to do. Still, it is currently defined as comprehensive care for a patient who presents with intense health-related suffering due to a serious, life-threatening illness. The goal of palliative care in dentistry is to improve the quality of life of patients, their families, and their caregivers. Based on the literature researched, it can be concluded that the most common oral conditions among palliative patients are xerostomia, candidiasis, mucositis, dysphagia, and dysgeusia. These conditions reduce the patient's quality of life, causing pain and discomfort. In addition, xerostomia is an important factor in the emergence of other conditions. Therefore, the presence of a dentist in the palliative care team is imperative to promote oral health

Major predictors of bruxism in pediatric dentistry: a systematic review

Introduction: There is difficulty in determining the prevalence of the habit of bruxism and therefore are important evaluation method, since only 5-20 % of the carrier population of habit are aware that perform the habit. Objective: This study aimed to conduct a quantitative and qualitative overview of the literature findings on the treatment of bruxism in pediatric dentistry. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from November 2024 to January 2025 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 112 articles were found, 42 articles were evaluated in full and 33 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 20 studies with a high risk of bias and 32 studies that did not meet GRADE. Most studies did not show homogeneity in their results, with X2=94.8%>50%. Some authors concluded that in children, there are several etiological factors of bruxism, such as psychological, local factors, occupational activities, and systemic conditions, factors such as stress and anxiety little considered the influence of allergic phenomena in this dysfunction. According to the author, in the allergic factor, nocturnal bruxism is from a reflex initiated by the increase in negative pressure in the tympanic cavities when there are successive allergic edemas in the mucosa in the Eustachian tubes. It is concluded that there are a large number of jobs in pediatric dentistry using muscle relaxant boards as a treatment for bruxism and temporomandibular disorder and according to the results obtained with a critical significance level, the vast majority of authors have confirmed the benefits of using the plates. It was concluded that bruxism has a multifactorial etiology because there is ample evidence that emotional stress is a major trigger, while occlusal interference is a predisposing factor. But some theories admit that occlusal disharmony is as etiological factor of bruxism