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Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways
Authors
Abram
Acton
+244 more
Alon
Alon
Attila Mócsai
Au-Yeung
Back
Bakker
Barlic
Barreda
Batliner
Bazzoni
Berger
Bergmeier
Block
Boey
Bonecchi
Borish
Borregaard
Borregaard
Bos
Bouchon
Bouchon
Boulay
Boyer
Braselmann
Brill
Brown
Bruhns
Cabal-Hierro
Camps
Camps
Carlow
Caron
Cassatella
Chen
Chen
Chesnutt
Colotta
Condliffe
Corey
Coxon
Croker
Crowley
Cua
Cui
Daigle
Dash-Koney
Deevi
Dib
Dinarello
Doring
Downey
Dri
Ekman
Elliott
Ellis
Eyles
Fasano
Ferguson
Fitzer-Attas
Fortin
Franchi
Franchi
Francois
Fridlender
Fumagalli
Futosi
Gadina
Gaffen
Gakidis
Galli
Gamble
Geering
Ghoreschi
Giagulli
Girard
Gounni
Graham
Graham
Gray-Owen
Gross
Gross
Guyre
Haan
Hanna
Hannigan
Haselmayer
Hayashi
Heit
Hewins
Hidalgo
Hirata
Hirsch
Hoarau
Hoffmann
Hortner
Hughes
Hurst
Ishikawa
Jakus
Jakus
Jakus
Jakus
Johnston
Jonsson
Jozsef
Jozsef
Kamohara
Kang
Kanneganti
Kaplanski
Kennedy
Kerrigan
Kiefer
Kilpatrick
Kim
Klebanoff
Knall
Koller
Kolls
Krisztina Futosi
Kuijpers
Kuijpers
Kulkarni
Kurt-Jones
Kuwano
Lee
Lee
Lefort
Lefort
Lehmann
Leung
Ley
Li
Li
Li
Liu
Liu
Loo
Lowell
Lowell
Luttrell
MacEwan
Malinin
Mankan
McColl
McDonald
McDowall
McGarrigle
McGrath
Medzhitov
Merck
Mermel
Migeotte
Monach
Monteiro
Monteseirin
Mora
Moresco
Moser
Mueller
Murphy
Musso
Mócsai
Mócsai
Mócsai
Mócsai
Mócsai
Mócsai
Mócsai
Mócsai
Nathan
Nathan
Neptune
Neptune
Newbrough
Nimrichter
Németh
Németh
O'Neill
O'Neill
O'Shea
Otten
Otten
Ouyang
Park
Pasvolsky
Pelletier
Pelletier
Pereira
Pereira
Porcherie
Rabiet
Rahimi
Ratthe
Renshaw
Repp
Rhyne
Riegel
Saijo
Saitoh
Salas
Sasaki
Sato
Scheel-Toellner
Schymeinsky
Schymeinsky
Shalaby
Smrcka
Smrcka
Smuda
Sperandio
Spriggs
Stadtmann
Stafforini
Stephens
Stylianou
Suzuki-Inoue
Svensson
Szabina Fodor
Talukdar
Tamassia
Taylor
Torchinsky
Totani
Turner
Urzainqui
Utomo
van Bruggen
van der Steen
Vella
Weinblatt
Wimmer
Woo
Yamasaki
Yamasaki
Ye
Zarbock
Zarbock
Zarbock
Zhang
Zhang
Zhou
Zhu
Zhu
Publication date
24 November 2015
Publisher
'Elsevier BV'
Doi
Cite
Abstract
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue damage during autoimmune and inflammatory diseases. Neutrophils express a large number of cell surface receptors for the recognition of pathogen invasion and the inflammatory environment. Those include G-protein-coupled chemokine and chemoattractant receptors, Fc-receptors, adhesion receptors such as selectins/selectin ligands and integrins, various cytokine receptors, as well as innate immune receptors such as Toll-like receptors and C-type lectins. The various cell surface receptors trigger very diverse signal transduction pathways including activation of heterotrimeric and monomeric G-proteins, receptor-induced and store-operated Ca2 + signals, protein and lipid kinases, adapter proteins and cytoskeletal rearrangement. Here we provide an overview of the receptors involved in neutrophil activation and the intracellular signal transduction processes they trigger. This knowledge is crucial for understanding how neutrophils participate in antimicrobial host defense and inflammatory tissue damage and may also point to possible future targets of the pharmacological therapy of neutrophil-mediated autoimmune or inflammatory diseases. © 2013 The Authors
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