This work was supported by the British Heart Foundation PG/10/37/28347, RG/10/11/28457, NIHR Biomedical Research Centre funding, and the ElectroCardioMaths Programme of the Imperial BHF Centre of Research Excellence

Akoum

Arya

B. Ariff

Badger

C. Juli

Cappato

Chao

D. Jones

D. Rueckert

D.P. Francis

D.W. Davies

Daccarett

Knowles

Kojodjojo

L.C. Malcolme-Lawes

Look

Maceira

McGann

N.S. Peters

Oakes

P. Kanagaratnam

P. Kojodjojo

P.B. Lim

Perez-David

Peters

R. Boubertakh

R. Hunter

R. Karim

R. Quest

R. Schilling

Rueckert

S. Jamil-Copley

S.E. Petersen

Taclas

Tedrow

Verma

W. Bai

Wnuk-Wojnar

Wylie

Heart Rhythm

English

PubMed

BackgroundFor late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) assessment of atrial scar to guide management and targeting of ablation in atrial fibrillation (AF), an objective, reproducible method of identifying atrial scar is required.ObjectiveTo describe an automated method for operator-independent quantification of LGE that correlates with colocated endocardial voltage and clinical outcomes.MethodsLGE CMR imaging was performed at 2 centers, before and 3 months after pulmonary vein isolation for paroxysmal AF (n = 50). A left atrial (LA) surface scar map was constructed by using automated software, expressing intensity as multiples of standard deviation (SD) above blood pool mean. Twenty-one patients underwent endocardial voltage mapping at the time of pulmonary vein isolation (11 were redo procedures). Scar maps and voltage maps were spatially registered to the same magnetic resonance angiography (MRA) segmentation.ResultsThe LGE levels of 3, 4, and 5SDs above blood pool mean were associated with progressively lower bipolar voltages compared to the preceding enhancement level (0.85 ± 0.33, 0.50 ± 0.22, and 0.38 ± 0.28 mV; P = .002, P < .001, and P = .048, respectively). The proportion of atrial surface area classified as scar (ie, >3 SD above blood pool mean) on preablation scans was greater in patients with postablation AF recurrence than those without recurrence (6.6% ± 6.7% vs 3.5% ± 3.0%, P = .032). The LA volume >102 mL was associated with a significantly greater proportion of LA scar (6.4% ± 5.9% vs 3.4% ± 2.2%; P = .007).ConclusionsLA scar quantified automatically by a simple objective method correlates with colocated endocardial voltage. Greater preablation scar is associated with LA dilatation and AF recurrence

Malcolme-Lawes, L.C.

Juli, C.

Karim, R.

Bai, W.

Quest, R.

Lim, P.B.

Jamil-Copley, S.

Kojodjojo, P.

Ariff, B.

Davies, D.W.

Rueckert, D.

Francis, D.P.

Hunter, R.

Jones, D.

Boubertakh, R.

Petersen, S.E.

Schilling, R.

Kanagaratnam, P.

Peters, N.S.

Elsevier - Publisher Connector 

Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study 

Malcolme-Lawes, LC

Juli, C

Karim, R

Bai, W

Quest, R

Lim, PB

Jamil-Copley, S

Kojodjojo, P

Ariff, B

Davies, DW

Rueckert, D

Francis, DP

Hunter, R

Jones, D

Boubertakh, R

Petersen, SE

Schilling, R

Kanagaratnam, P

Peters, NS

Queen Mary Research Online

3-D visualization of acute RF ablation lesions using MRI for the simultaneous determination of the patterns of necrosis and edema.

Association of left atrial fibrosis detected by delayed-enhancement magnetic resonance imaging and the risk of stroke in patients with atrial fibrillation.

Associations among the CHADS(2) score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation. Heart Rhythm 2011;8:1155–1159.

Atrial fibrosis helps select the appropriate patient and strategy in catheter ablation of atrial fibrillation: a DEMRI guided approach.

Circumferential pulmonary vein RF ablation in the treatment of atrial fibrillation: 3-year experience of one centre. Kardiol Pol 2005;63:362–370; discussion 371–372.

Detection and quantification of left atrial structural remodeling with delayed-enhancement magnetic resonance imaging in patients with atrial fibrillation.

Detection of pulmonary vein and left atrial scar after catheter ablation with three-dimensional navigator-gated delayed enhancement MR imaging: initial experience. Radiology

Evaluation of left atrial lesions after initial and repeat atrial fibrillation ablation: lessons learned from delayedenhancement MRI in repeat ablation procedures. Circ Arrhythm Electrophysiol 2010;3:249–259.

Evaluation of myocardial viability by MRI. Herz

Left atrial function and scar after catheter ablation of atrial fibrillation. Heart Rhythm

Long-term results and the predictors of outcome of catheter ablation of atrial fibrillation using steerable sheath catheter navigation after single procedure in 674 patients.

MRI in cardiac electrophysiology: the emerging role of delayed-enhancement MRI in atrial fibrillation ablation. Future Cardiol

New magnetic resonance imaging-based method for defining the extent of left atrial wall injury after the ablation of atrial fibrillation.

Nonrigid registration using free-form deformations: application to breast MR images.

Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure.

Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation.

Recording and interpreting unipolar electrograms to guide catheter ablation. Heart Rhythm 2011;8:791–796.

Recurrence of atrial fibrillation correlates with the extent of post-procedural late gadolinium enhancement: a pilot study.

Reference left atrial dimensions and volumes by steady state free precession cardiovascular magnetic resonance.

Relationship between intended sites of RF ablation and post-procedural scar in AF patients, using late gadolinium enhancement cardiovascular magnetic resonance. Heart Rhythm 2010;7:489–496.

Response of atrial fibrillation to pulmonary vein antrum isolation is directly related to resumption and delay of pulmonary vein conduction.

Temporal left atrial lesion formation after ablation of atrial fibrillation. Heart Rhythm

The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction.

Time saving in measurement of NMR and EPR relaxation times. Rev Sci Instrum 1970;41:250–251.

Updated worldwide survey on the methods, efficacy, and safety of catheter ablation for human atrial fibrillation. Circ Arrhythm Electrophysiol 2010;3:32–38.

Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study

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https://qmro.qmul.ac.uk/xmlui/bitstream/handle/123456789/9717/Petersen%20Automated%20analysis%20of%20atrial%202013%20Published.pdf?sequence=3

Automated analysis of atrial late gadolinium enhancement imaging that correlates with endocardial voltage and clinical outcomes: A 2-center study

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