The following funding bodies supported this work: Biotechnology and Biological Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB). IH is supported by a Medical Research Council (MRC, G0802796) PhD studentship

Allen

Allende

Badylak

Bancos

Berkes

Birke

Buaas

Chamoux

Clipsham

Cogger

Crawford

Drucker

Dubernard

El-Khairi

Else

Faulk

Fayard

Franksson

Freedman

Gallo-Payet

Gondo

Grodstein

Guasti

Hardy

Hatano

Huang

Ibbertson

Jadhav

Kearns

King

Laufer

Ludwig

Mazilu

Parker

Sancho-Martinez

Schimmer

Schnabel

Sonoyama

Takahashi

Tanaka

Teebken

Thomas

Vierbuchen

Vouillarmet

Walczak

Wilhelm

Wong

Yazawa

Zupekan

Frontiers in Endocrinology

English

PubMed

Adrenal disease, whether primary, caused by defects in the hypothalamic-pituitary-adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of corticosteroids. However this kind of therapy is far from ideal as physiological demand for steroids varies considerably throughout the day and increases during periods of stress. The development of alternative curative strategies is therefore needed. In this review we describe the latest technologies aimed at either isolating or generating de novo cells that could be used for novel, regenerative medicine application in the adrenocortical field

Gerard eRuiz-Babot

Irene eHadjidemetriou

Peter James King

Leonardo eGuasti

Directory of Open Access Journals

New directions for the treatment of adrenal insufficiency.

Ruiz-Babot, G

Hadjidemetriou, I

King, PJ

Guasti, L

Queen Mary Research Online

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Recent advances in cell replacement therapies for the treatment of type 1 diabetes. Endocrinology

Role of the extracellular matrix in whole organ engineering.

Sciences Research Council (BBSRC BB/L00267/1, to LG), Rosetrees Trust (to LG), Barts and The London Charity (417/2235, to LG), EU COFUND (PCOFUND-GA-2013-608765, to LG and GRB). IH is supported by a Medical Research Council (MRC,

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Steroidogenic factor 1: a key determinant of endocrine development and function. Endocr Rev

Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.

Steroidogenic factor-1 (SF-1)-driven differentiation of murine embryonic stem (ES) cells into a gonadal lineage. Endocrinology

Storage and autotransplantation of human adrenal tissue. Acta Chir Scand

Surgical management of Cushing’s syndrome with emphasis on adrenal autotransplantation. Ann Surg

The extracellular matrix as a scaffold for tissue reconstruction. Cell Dev Biol

The first simultaneous kidney-adrenal gland-pancreas transplantation: outcome at 1 year.

Therapeutic genome editing: prospects and challenges. Nat Med (2015) 21(2):121–31. doi:10.1038/nm.3793 Conflict of Interest Statement: The authors declare that the research was conducted

New directions for the treatment of adrenal insufficiency

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