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research
Factors impacting antiretroviral therapy adherence among human immunodeficiency virus-positive adolescents in Sub-Saharan Africa: a systematic review
Authors
Adejumo
Agwu
+101 more
AIDS.gov
AIDSinfo
AIDSinfo
Ankrah
Bernays
Bezabhe
Bhattacharya
Bikaako-Kajura
Birungi
Braitstein
Bygrave
Centers for Disease Control and Prevention
Cluver
Cohen
Critical Appraisal Skills Programme
Danford
Deeks
Denison
Fair
Famoroti
Ferrara
Fetzer
Finocchario-Kessler
Fongkaew
Gross
Gulick
Haberer
Habib
Harries
Hodgson
Hogwood
Hudelson
J.M. Corkery
Jaspan
Joint United Nations Programme on HIV/AIDS
Katz
Kawuma
Kim
King
Kirk
Klitzman
Krauss
Kunapareddy
Lall
Langat
Lowenthal
Lyimo
Maartens
MacPherson
Manglos
Mavhu
Mbirimtengerenji
Mburu
Mburu
Michaud
Mills
Moon
Murphy
Musumari
Mutumba
Mutwa
N. Ammon
Nabukeera-Barungi
Nachega
Nachega
Nachega
Nachega
National Institutes of Health
Nyogea
Nöstlinger
O'Brien
Park
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Reda
Reisner
Remien
Roberts
Ross-Degnan
S. Mason
Scanlon
Simoni
Sithole
Siu
Sivapalasingam
Thomas
Tumwine
United Nations International Children's Emergency Fund
United Nations International Children's Emergency Fund
Vaz
Vreeman
Vreeman
Vyas
Wanyama
Wasti
Watt
Wiener
World Health Organization
World Health Organization
World Health Organization
World Health Organization
Zou
Publication date
20 March 2019
Publisher
'Elsevier BV'
Doi
Cite
Abstract
© 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.Objectives: Eighty-two percent of human immunodeficiency virus (HIV)–positive adolescents live in Sub-Saharan Africa (SSA). Despite the availability of antiretroviral therapy (ART), adherence levels are suboptimal, leading to poor outcomes. This systematic review investigated factors impacting ART adherence among adolescents in SSA, including religious beliefs and intimate relationships. Methods: A systematic review was conducted between June and August 2016 using eight electronic databases, including Cochrane and PubMed. Published, ongoing and unpublished research, conducted in SSA from 2004 to 2016, was identified and thematic analysis was used to summarise findings. Results: Eleven studies from eight SSA countries, published in English between 2011 and 2016, reported on factors impacting ART adherence among adolescents living with HIV (ALHIV). Forty-four barriers and 29 facilitators to adherence were identified, representing a complex web of factors. The main barriers were stigma, ART side-effects, lack of assistance and forgetfulness. Facilitators included caregiver support, peer support groups and knowledge of HIV status. Conclusions: Stigma reflects difficult relations between ALHIV and their HIV-negative peers and adults. Most interventions target only those with HIV, suggesting a policy shift towards the wider community could be beneficial. Recommendations include engaging religious leaders and schools to change negative societal attitudes. Limitations of the review include the urban settings and recruitment of predominantly vertically infected participants in most included studies. Therefore, the findings cannot be extrapolated to ALHIV residing in rural locations or horizontally infected ALHIV, highlighting the need for further research in those areas.Peer reviewedFinal Accepted Versio
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info:doi/10.1016%2Fj.puhe.2017...
Last time updated on 26/01/2021
University of Hertfordshire Research Archive
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oai:uhra.herts.ac.uk:2299/2089...
Last time updated on 09/03/2020