Agarwal

Amarenco

Ammi

Avery

Bellette

Bonniaud

Booth

Burton

Chen

Coyne

De Seze

Donaldson

Finazzi-Agro

Gaziev

Haab

Haylen

Higgins

Homma

Irwin

Kinsey

Leary

Levin

Lucas

Manriques

Milsom

Moher

Monga

Monteiro

Moossdorff-Steinhauser

Nyström

Patrick

Perissinotto

Peters

Schneider

Schreiner

Souto

Stewart

Stoller

Surbala

Svihra

Uebersax

Vaughan

Veenboer

Wagg

English

Joanne Booth

Lesley Connelly

Sylvia Dickson

Fiona Duncan

Maggie Lawrence

Crossref

Neurourology and Urodynamics

The effectiveness of transcutaneous tibial nerve stimulation (TTNS) for adults with overactive bladder syndrome: A systematic review

Aims: To evaluate effectiveness of transcutaneous tibial nerve stimulation (TTNS) for treating adults with overactive bladder (OAB) of idiopathic or neurogenic origin, using a systematic review of the literature. Methods: Systematic searches of four databases were undertaken between 1980 and 2017. Included studies investigated effects of TTNS on OAB. Study selection, data extraction, quality appraisal was performed by two independent reviewers. Narrative analysis was undertaken where meta-analysis was not possible due to study heterogeneity. Meta-analysis of RCTs was performed using a fixed effects model.Results: Ten RCTs and three prospective cohort studies involving 629 participants were reviewed. Meta-analysis of two trials comparing TTNS with sham showed mean reduction in total ICIQ Urinary Incontinence Short Form (ICIQ-UI SF) associated with TTNS of -3.79 (95% CI -5.82, -1.76; P = 0.0003, I2 = 25%). Narrative review showed TTNS and antimuscarinic treatment were equally effective (four trials), TTNS provided greater benefit for OAB symptoms than behavioral interventions (two trials), tibial nerve, and sacral foramen stimulation were equally effective but combined stimulation was most effective (one trial). Significant improvements in OAB symptoms were reported by 48-93% participants and UI cure rates of 25-45%. No adverse events were reported.Conclusions: Limited evidence is provided that TTNS is an effective, safe intervention for idiopathic OAB in adults and may be of benefit in those with neurogenic OAB. Further studies are essential to confirm these results as well as to determine efficacy and associated costs for specific patient groups,most effective stimulation dosage, duration of effect, and stimulation regimes for longer-term maintenance

Booth, Joanne

Connelly, Lesley

Dickson, Sylvia

Duncan, Fiona

Lawrence, Maggie

ResearchOnline@GCU

The effectiveness of transcutaneous tibial nerve stimulation (TTNS) for adults with overactive bladder syndrome: a systematic review

https://researchonline.gcu.ac.uk/files/25192405/Booth_AcceptedPaper_Jul17_2_.pdf

The effectiveness of transcutaneous tibial nerve stimulation (TTNS) for adults with overactive bladder syndrome: a systematic review

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ResearchOnline@GCU