CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
research
The Initial Slope of the Variogram, Foundation of the Trabecular Bone Score, Is Not or Is Poorly Associated With Vertebral Strength.
Authors
Bousson
Bousson
+37 more
Burghardt
Chevalier
Dall'Ara
Dall'Ara
Dall'Ara
Dempster
Dong
Dong
Fyhrie
Garrigues
Hans
Hans
Iki
Iki
Johnell
Krueger
Lin
Lippuner
Lochmüller
Lu
Maquer
Maquer
Maquer
McCloskey
Muschitz
Naylor
Paggiosi
Pothuaud
Roux
Silva
Smith
Stone
Touvier
Varga
Winzenrieth
Yang
Zysset
Publication date
3 September 2015
Publisher
'Wiley'
Doi
Cite
Abstract
Trabecular bone score (TBS) rests on the textural analysis of dual-energy X-ray absorptiometry (DXA) to reflect the decay in trabecular structure characterizing osteoporosis. Yet, its discriminative power in fracture studies remains incomprehensible because prior biomechanical tests found no correlation with vertebral strength. To verify this result possibly owing to an unrealistic setup and to cover a wide range of loading scenarios, the data from three previous biomechanical studies using different experimental settings were used. They involved the compressive failure of 62 human lumbar vertebrae loaded 1) via intervertebral discs to mimic the in vivo situation ("full vertebra"); 2) via the classical endplate embedding ("vertebral body"); or 3) via a ball joint to induce anterior wedge failure ("vertebral section"). High-resolution peripheral quantitative computed tomography (HR-pQCT) scans acquired from prior testing were used to simulate anterior-posterior DXA from which areal bone mineral density (aBMD) and the initial slope of the variogram (ISV), the early definition of TBS, were evaluated. Finally, the relation of aBMD and ISV with failure load (Fexp ) and apparent failure stress (σexp ) was assessed, and their relative contribution to a multilinear model was quantified via ANOVA. We found that, unlike aBMD, ISV did not significantly correlate with Fexp and σexp , except for the "vertebral body" case (r(2) = 0.396, p = 0.028). Aside from the "vertebra section" setup where it explained only 6.4% of σexp (p = 0.037), it brought no significant improvement to aBMD. These results indicate that ISV, a replica of TBS, is a poor surrogate for vertebral strength no matter the testing setup, which supports the prior observations and raises a fortiori the question of the deterministic factors underlying the statistical relationship between TBS and vertebral fracture risk. © 2015 American Society for Bone and Mineral Research
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Bern Open Repository and Information System (BORIS)
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:boris.unibe.ch:70967
Last time updated on 06/05/2016
White Rose Research Online
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:eprints.whiterose.ac.uk:90...
Last time updated on 22/10/2015
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
info:doi/10.1002%2Fjbmr.2610
Last time updated on 13/02/2019