Cormac Hally

Cristiano Viappiani

Pietro Delcanale

Santi Nonell

Stefania Abbruzzetti

English

Crossref

Photosensitizing proteins for antibacterial photodynamic inactivation

We review recent applications of water‐soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of the compounds. Taking advantage of the spontaneous interaction between water soluble proteins endowed with hydrophobic cavities and the otherwise insoluble photosensitizing compounds, it is possible to obtain efficient delivery systems to be applied inaPDT. These self‐assembled structures are endowed with good photosensitizing and fluorescence emission properties (comparable to those of monomerized photosensitizers) with high biocompatibility and warrant good bioavailability of the photoactive drug. The proteins used so far comprise serum albumins, β‐lactoglobulin, and apomyoglobin, while photosensitizers considered up to now have been hypericin, curcumin, Zn‐protoporphyrin IX, and Zn‐phthalocyanine. Furthermore, mutants of fluorescent proteins derived from GFP‐like systems or from flavin binding proteins complete the array of available photosensitizing proteins for aPDT

Nonell, Santi

Hally, Cormac

Delcanale, Pietro

Viappiani, Cristiano

Abbruzzetti, Stefania

DAU - Digital Archive of URL (Ramon Llull University)

We review recent applications of water-soluble proteins as carriers for photosensitizing molecules in antimicrobial photodynamic therapy (aPDT). The low water solubility of photosensitizers and their tendency to aggregate often impair their photophysics, thus resulting in lower bioavailability of the compounds. Taking advantage of the spontaneous interaction between water soluble proteins endowed with hydrophobic cavities and the otherwise insoluble photosensitizing compounds, it is possible to obtain efficient delivery systems to be applied inaPDT. These self-assembled structures are endowed with good photosensitizing and fluorescence emission properties (comparable to those of monomerized photosensitizers) with. high biocompatibility and warrant good bioavailability of the photoactive drug. The proteins used so far comprise serum albumins, beta-lactoglobulin, and apomyoglobin, whilst photosensitizers considered up to now have been hypericin, curcumin, Zn-protoporphyrin IX, and Zn-phthalocyanine.
Furthermore, mutants of fluorescent proteins derived from GFP-like systems or from flavin binding proteins complete the array of available photosensitizing proteins for aPDT

Archivio istituzionale della Ricerca -  Università degli Studi di Parma

https://www.openaccessrepository.it/record/31066/files/fulltext.pdf

photosensitizing proteins for antibacterial photodynamic inactivation

photosensitizing proteins for antibacterial photodynamic inactivation

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Crossref

DAU - Digital Archive of URL (Ramon Llull University)

Archivio istituzionale della Ricerca - Università degli Studi di Parma