Modelling the effects of calcium waves and oscillations on saliva secretion

Abstract

An understanding of Ca2+Ca2+ signalling in saliva-secreting acinar cells is important, as Ca2+Ca2+ is the second messenger linking stimulation of cells to production of saliva. Ca2+Ca2+ signals affect secretion via the ion channels located both apically and basolaterally in the cell. By approximating Ca2+Ca2+ waves with periodic functions on the apical and basolateral membranes, we isolate individual wave properties and investigate them for their effect on fluid secretion in a mathematical model of the acinar cell. Mean Ca2+Ca2+ concentration is found to be the most significant property in signalling secretion. Wave speed was found to encode a range of secretion rates. Ca2+Ca2+ oscillation frequency and amplitude had little effect on fluid secretion