Bains

Birnbaumer

Csicsvari

F. Zheng

Funahashi

J. Abramowitz

K. D. Phelan

Kapur

Kwon

L. Birnbaumer

Mazarati

Mazzuferi

Mulle

Perez-Leighton

Rice

Stoop

U. T. Shwe

Significance
          Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels. TRPC7 was the last member of the TRPC family cloned, and the functional role of TRPC7 in the brain is completely unknown. Here, we show that genetic ablation of TRPC7 disrupts acute severe seizures induced by pilocarpine in mice. This disruption is associated with a reduction in pilocarpine-induced increase in gamma wave activity that precedes the acute seizures. At the cellular level, loss of TRPC7 shows reduced long-term potentiation at cornu ammonis (CA) 3 recurrent collateral synapses, which is critical for the generation of epileptiform burst firing in the CA3 region of the hippocampus. Our findings reveal a critical role for TRPC7 in the generation of seizures.</jats:p

Kevin D. Phelan

U Thaung Shwe

Joel Abramowitz

Lutz Birnbaumer

Fang Zheng

Crossref

Proceedings of the National Academy of Sciences

Critical role of canonical transient receptor potential channel 7 in initiation of seizures

Critical role of canonical transient receptor potential channel 7 in initiation of seizures

Abstract

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