Brodehl

Chillarón

Enomoto

Feliubadaló

Furriols

Hirohisa Okuyama

Junko Kurokawa

Kanai

Kazuaki Takafuji

Kenjiro Tadagaki

Manuel Palacín

Meritxell Espino Guarch

Pattama Wiriyasermkul

Ryuichi Ohgaki

Saya Nakagomi

Shayakul

Shushi Nagamori

Stephens

Suguru Okuda

Susanna Bodoy

Virginia Nunes

Yoshikatsu Kanai

Yumiko Nishinaka

Significance
          Although molecular identification of transporters in mammals seems almost settled, some long-proposed transporters still remain to be revealed. The second cystine transporter in renal cystine reabsorption is one of such transporters. Its genetic defect has been proposed to be responsible for a type of cystinuria distinct from that caused by the mutations of the already known cystine transporter. In this study, we have found a membrane protein SLC7A13 as the second cystine transporter with proposed characteristics, and provided a possible clue to the genetics of previously unidentified cystinuria. Intricate functional coupling of SLC7A13 with the nearby glutamate transporter is also proposed. We have solved long-lasting problems in renal cystine transport physiology and paradoxes regarding the unmatched distribution of cystine transporter components.</jats:p

Crossref

Proceedings of the National Academy of Sciences

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

Abstract

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