Generally, the present disclosure is directed to optimizing tuning parameters in a computing system and/or software application using machine learning. In particular, in some implementations, the systems and methods of the present disclosure can include or otherwise leverage one or more machine-learned models to predict an optimal value for tuning parameters based on metrics provided by a developer. As examples, such metrics may be related to an amount of user engagement, latency associated with the application, or efficiency of executing the software application