A Study of the Hoesch-Houben Synthesis in the Preparation of Aromatic Ketimines and Hydroxy-Phenyl Iminoesters

Abstract

This synthesis involves the condensation of a phenol with a nitrile (aliphatic or aromatic). It is effected by the passage of dry hydrogen chloride through their solution in anhydrous ether, with or without the addition of dry zinc chloride. Anhydrous aluminum chloride was substituted for zinc chloride in some cases