Although there is substantial comorbidity between psychotic disorder and obsessive-compulsive disorder (OCD), little is known about how these clinical phenotypes, and their subclinical extended phenotypes, covary and impact on each other over time. This study examined cross-sectional and longitudinal associations between both (extended) phenotypes in the general population.status: publishe

Association

Berman

Bijl

Bland

Bora

Braga

Byerly

Cottler

Cromer

Crum

Darroch

De Bruijn

De Graaf

Denys

Eisen

Fabisch

Freeman

Goldberg

Goodwin

Gross-Isseroff

Hanssen

Hultman

Jahrreis

Jenike

Johns

Karno

Kaymaz

Klein

Kolada

Krabbendam

Lewis

Lukoff

Lysaker

Maher

Mancebo

Maric

Nechmad

Niendam

Ongur

Overall

Phelan

Poyurovsky

Read

Reay

Regeer

Robins

Ruscio

Salkovskis

Scott

Slade

Spinella

Spitzer

StataCorporation

Stein

Svirskis

Tien

Van Os

Vasconcelos

Weiser

Weissman

Westphal

Wittchen

Zohar

English

Objective: Although there is substantial comorbidity between psychotic disorder and obsessive-compulsive disorder (OCD), little is known about how these clinical phenotypes, and their subclinical extended phenotypes, covary and impact on each other over time. This study examined cross-sectional and longitudinal associations between both (extended) phenotypes in the general population.Method: Data were obtained from the three waves of the NEMESIS-study. A representative population sample of 7076 participants were assessed using the composite international diagnostic interview (CIDI) at baseline (

van Dael, F.

van Os, J

de Graaf, R.

ten Have, M.

Krabbendam, L.

Myin-Germeys, I.

VU Research Portal

Can obsessions drive you mad? Longitudinal evidence that obsessive-compulsive symptoms worsen the outcome of early psychotic experiences

Objective: Although there is substantial comorbidity between psychotic disorder and obsessive-compulsive disorder (OCD), little is known about how these clinical phenotypes, and their subclinical extended phenotypes, covary and impact on each other over time. This study examined cross-sectional and longitudinal associations between both (extended) phenotypes in the general population. Method: Data were obtained from the three waves of the NEMESIS-study. A representative population sample of 7076 participants were assessed using the composite international diagnostic interview (CIDI) at baseline (T-0), 1 year later at T-1 and again 2 years later at T-2. Results: At T-0, a lifetime diagnosis of psychotic disorder was present in 1.5% of the entire sample, in 11.5% of the people with any OC symptom and in 23.0% of individuals diagnosed with OCD. OC symptoms at T-0 predicted incident psychotic symptoms at T-2. Similarly, T-0 psychotic symptoms predicted T-2 OC symptoms. The likelihood of persistence of psychotic symptoms or transition to psychotic disorder was higher if early psychosis was accompanied by co-occurring OC symptoms, but not the other way around. Conclusion: OCD and the psychosis phenotype cluster together and predict each other at (sub)clinical level. The co-occurrence of subclinical OC and psychosis may facilitate the formation of a more 'toxic' form of persistent psychosis

Van Dael, Frank

van Os, J.

Krabbendam, Lydia

Maastricht University Research Portal

Dael, F. van

Os, J van

Graaf, R. de

Have, M. ten

DSpace at VU

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