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Histological findings of autoimmune hepatitis
Authors
A Tanaka
CL Langrish
+37 more
D Vergani
EM Hennes
F Alvarez
F Ichida
G Fmcs
H Hofer
H Lohr
H Lohr
H Niwa
H Ohira
HP Dienes
J Misdraji
K Harada
K Harada
K Hiramatsu
K Ishak
KM Boberg
KP Batts
L Zhao
M Abe
M Guindi
M Oketani
M Onji
M Onji
M Peiseler
MS Longhi
MS Longhi
O Chazouilleres
Paola Loria
PJ Scheuer
RT Stravitz
S Kotake
S Nakae
Y Ichiki
Y Nakanuma
Y Zen
Y Zen
Publication date
1 August 2014
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
Histology of autoimmune hepatitis (AIH), chronic active hepatitis, is characterized by portal inflammation with interface hepatitis. Although the basic histology of AIH is similar to that of virus-related chronic hepatitis, hepatitic changes are usually prominent in AIH compared with chronic viral hepatitis. Clinicopathological diagnosis of AIH requires exclusion of other causes of liver disease, including hepatitis virus, alcohol, drugs, metabolic disorders, and other autoimmune diseases. At present, some criteria systems considering clinicopathological findings are proposed to categorize patients as having either definite or probably/atypical AIH. Among the pathological items of a simplified AIH scoring system of the International AIH Group, in addition to evident chronic hepatitis with interface hepatitis and hepatic rosette formation, emperipolesis, indicating the close immunological interaction of lymphocytes and hepatocytes, is noted but is sometimes difficult to evaluate. In addition to classical AIH, showing chronic active hepatitis, some AIH patients show a clinically acute hepatitis-like clinical course. These patients have mostly acute exacerbation from chronic active AIH, but acute-onset AIH cases, which histologically exhibit diffuse lobular hepatitis and/or confluent necrosis including perivenular zonal necrosis (zone 3 necrosis, centrizonal necrosis), are also encountered. © 2014 Springer Japan. All rights reserved.(Book Chapter
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info:doi/10.1007%2F978-4-431-5...
Last time updated on 05/06/2019
Kanazawa University Repository for Academic Resources
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Last time updated on 06/05/2019