Proposed model for the role of RbgA in promoting late-stage large ribosome subunit assembly.

Abstract

<p>A late assembly intermediate (LAI<sub>50-1</sub>) can proceed via two different pathways. Pathway 1 posits that RbgA binds prior to L6 (LAI<sub>50-2</sub>) while pathway 2 indicates L6 binds prior to RbgA (LAI<sub>50-3</sub>). When bound together (LAI<sub>50-4</sub>), RbgA facilitates proper interaction between L6 and the maturing ribosome, which triggers the incorporation of late ribosomal proteins. Once proper incorporation occurs, RbgA leaves the complex. The role of GTP hydrolysis in the assembly process is discussed in the text.</p

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