Diastereoselective Synthesis of Indanes and Tetralins via Intramolecular Friedel–Crafts Reaction

Abstract

An easy access to tetralin and indane skeletons has been developed using a diastereoselective intramolecular Friedel–Crafts alkylation. Treatment of diastereomeric mixtures of benzyl carbinols with a catalytic amount of Ca(NTf<sub>2</sub>)<sub>2</sub>/Bu<sub>4</sub>NPF<sub>6</sub> yields the respective tetralin or indane in good yields with high levels of regio- and diastereoselectivity

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