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Bone pain and extremely low bone mineral density due to severe vitamin D deficiency in celiac disease
Authors
A Taranta
C Garcia-Porrua
+28Β more
CE Fiore
E Kozanoglu
GR Corazza
GW Hepner
Hans M. Westgeest
I DM Van
JR Walters
K Mustalahti
KK Miller
KS Sher
LR Pistorius
M Staun
Maarten A. J. M. Jacobs
MJ Farthing
MR Clements
N Molteni
Nathalie Bravenboer
Noortje M. Rabelink
P Lips
Paul Lips
PL Riches
RA Basu
RS Weinstein
S Balsan
T Valdimarsson
T Valdimarsson
WA Boer De
XA McFarlane
Publication date
1 January 2011
Publisher
Springer-Verlag
Doi
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on
PubMed
Abstract
Case report A 29-year-old wheelchair-bound woman was presented to us by the gastroenterologist with suspected osteomalacia. She had lived in the Netherlands all her life and was born of Moroccan parents. Her medical history revealed iron deficiency, growth retardation, and celiac disease, for which she was put on a gluten-free diet. She had progressive bone pain since 2 years, difficulty with walking, and about 15 kg weight loss. She had a short stature, scoliosis, and pronounced kyphosis of the spine and poor condition of her teeth. Laboratory results showed hypocalcemia, an immeasurable serum25-hydroxyvitamin D level, and elevated parathyroid hormone and alkaline phosphatase levels. Spinal radiographs showed unsharp, low contrast vertebrae. Bone mineral density measurement at the lumbar spine and hip showed a T-score of -6.0 and -6.5, respectively. A bone scintigraphy showed multiple hotspots in ribs, sternum, mandible, and long bones. A duodenal biopsy revealed villous atrophy (Marsh 3C) and positive antibodies against endomysium, transglutaminase, and gliadin, compatible with active celiac disease. A bone biopsy showed severe osteomalacia but normal bone volume. She was treated with calcium intravenously and later orally. Furthermore, she was treated with high oral doses of vitamin D and a gluten-free diet. After a few weeks of treatment, her bone pain decreased, and her muscle strength improved. Discussion In this article, the pathophysiology and occurrence of osteomalacia as a complication of celiac disease are discussed. Low bone mineral density can point to osteomalacia as well as osteoporosis. Β© International Osteoporosis Foundation and National Osteoporosis Foundation 2011
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