In older women SHBG and estradiol are independently associated with inflammatory markers, suggesting a protective role of SHBG and the negative role of estradiol in cardiovascular disease

Anna Maria Corsi

Bell

Brand

Braunstein

Chiara Cattabiani

Couzinet

Crandall

Ding

Elisabetta Dall'Aglio

Fabrizio Ablondi

Ferrucci

Folsom

Francesco Giallauria

Fulvio Lauretani

Giallauria

Gian Paolo Ceda

Giovanni Zuliani

Graziano Ceresini

Heinlein

Jack M. Guralnik

Joffe

Kahn

Lamberts

Luigi Ferrucci

Maggio

Marcello Maggio

Maturana

Mudali

Onat

Ouyang

Patel

Perry

Rexrode

Rinaudo

Shehzad Basaria

Stefania Bandinelli

Stefano Parrino

Stenholm

Störk

Zhao

Zuliani

PubMed

Abstract
               
                  Context:
                  In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation.
               
               
                  Objective:
                  The aim of the study was to examine the relationship between SHBG, total testosterone, total E2, and inflammatory markers in older women.
               
               
                  Design and Patients:
                  We conducted a retrospective cross-sectional study of 433 women at least 65 yr old from the InCHIANTI Study, Italy, who were not on hormone replacement therapy or recently hospitalized and who had complete data on SHBG, testosterone, E2, C-reactive protein (CRP), IL-6, soluble IL-6 receptor (sIL-6r), and TNF-α. Relationships between sex hormones and inflammatory markers were examined by multivariate linear regression analyses adjusted for age, body mass index, smoking, insulin, physical activity, and chronic disease.
               
               
                  Results:
                  In fully adjusted analyses, SHBG was negatively associated with CRP (P = 0.007), IL-6 (P = 0.008), and sIL-6r (P = 0.02). In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-α (P = 0.0002). The negative relationship between testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no longer significant in a fully adjusted model (P = 0.12). E2 was positively associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models. In a final model including E2, testosterone, and SHBG, and all the confounders previously considered, SHBG (0.23 ± 0.08; P = 0.006) and E2 (0.21 ± 0.08; P = 0.007), but not testosterone (P = 0.21), were still significantly associated with CRP.
               
               
                  Conclusion:
                  In late postmenopausal women not on hormone replacement therapy, SHBG and E2 are, respectively, negative and positive, independent and significant correlates of a proinflammatory state.
               </jats:sec

Crossref

The Journal of Clinical Endocrinology & Metabolism

SHBG, Sex Hormones, and Inflammatory Markers in Older Women

CONTEXT:
In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation.

OBJECTIVE:
The aim of the study was to examine the relationship between SHBG, total testosterone, total E2, and inflammatory markers in older women.

DESIGN AND PATIENTS:
We conducted a retrospective cross-sectional study of 433 women at least 65 yr old from the InCHIANTI Study, Italy, who were not on hormone replacement therapy or recently hospitalized and who had complete data on SHBG, testosterone, E2, C-reactive protein (CRP), IL-6, soluble IL-6 receptor (sIL-6r), and TNF-α. Relationships between sex hormones and inflammatory markers were examined by multivariate linear regression analyses adjusted for age, body mass index, smoking, insulin, physical activity, and chronic disease.

RESULTS:
In fully adjusted analyses, SHBG was negatively associated with CRP (P = 0.007), IL-6 (P = 0.008), and sIL-6r (P = 0.02). In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-α (P = 0.0002). The negative relationship between testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no longer significant in a fully adjusted model (P = 0.12). E2 was positively associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models. In a final model including E2, testosterone, and SHBG, and all the confounders previously considered, SHBG (0.23 ± 0.08; P = 0.006) and E2 (0.21 ± 0.08; P = 0.007), but not testosterone (P = 0.21), were still significantly associated with CRP.

CONCLUSION:
In late postmenopausal women not on hormone replacement therapy, SHBG and E2 are, respectively, negative and positive, independent and significant correlates of a proinflammatory state

Maggio, Marcello

Ceda, Gian Paolo

Lauretani, Fulvio

Bandinelli, Stefania

Corsi, Anna Maria

Giallauria, Francesco

Guralnik, Jack M.

Zuliani, Giovanni

Cattabiani, Chiara

Parrino, Stefano

Ablondi, Fabrizio

Dall'aglio, Elisabetta

Ceresini, Graziano

Basaria, Shehzad

Ferrucci, Luigi

Archivio della ricerca - Università degli studi di Napoli Federico II

SHBG, sex hormones, and inflammatory markers in older women

In premenopausal and older women, high testosterone and estradiol 
(E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions 
characterized by low-grade inflammation.
Objective: The aim of the study was to examine the relationship between SHBG, 
total testosterone, total E2, and inflammatory markers in older women.
Design and Patients: We conducted a retrospective cross-sectional study of 433 
women at least 65 yr old from the InCHIANTI Study, Italy, who were not on hormone replacement 
therapy or recently hospitalized and who had complete data on SHBG, testosterone, E2, C-reactive 
protein (CRP), IL-6, soluble IL-6 receptor (sIL-6r), and TNF-. Relationships between sex hormones 
and inflammatory markers were examined by multivariate linear regression analyses adjusted for 
age, body mass index, smoking, insulin, physical activity, and chronic disease.
Results: In fully adjusted analyses, SHBG was negatively associated with CRP 
(P  0.007), IL-6 (P  0.008), and sIL-6r (P0.02). In addition, testosterone was positively 
associated with CRP (P0.006), IL-6 (P0.001), and TNF- (P0.0002). The negative relationship between 
testosterone and sIL-6r in an age-adjusted model (P  0.02) was no longer significant in a fully 
adjusted model (P  0.12). E2 was positively associated with CRP (P0.002) but not with IL-6 in fully 
adjusted models. In a final model including E2, testosterone, and SHBG, and all the confounders previously 
considered, SHBG (0.23  0.08; P  0.006) and E2 (0.21  0.08; P  0.007), but not testosterone 
(P  0.21), were still significantly associated with CRP.
Conclusion: In late postmenopausal women not on hormone replacement therapy, 
SHBG and E2 are, respectively, negative and positive, independent and significant 
correlates of a proinflammatory state

MAGGIO, Marcello Giuseppe

CEDA, Gian Paolo

CERESINI, Graziano

Lauretani F

Bandinelli S

Corsi AM

Giallauria F

Guralnik JM

Zuliani G

Cattabiani C

Parrino S

Ablondi F

DALL'AGLIO, Elisabetta

Basaria S

Ferrucci L.

Archivio istituzionale della Ricerca -  Università degli Studi di Parma

SHBG, sex hormones, and inflammatory markers in older women.

Abstract
CONTEXT:

In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation.
OBJECTIVE:

The aim of the study was to examine the relationship between SHBG, total testosterone, total E2, and inflammatory markers in older women.
DESIGN AND PATIENTS:

We conducted a retrospective cross-sectional study of 433 women at least 65 yr old from the InCHIANTI Study, Italy, who were not on hormone replacement therapy or recently hospitalized and who had complete data on SHBG, testosterone, E2, C-reactive protein (CRP), IL-6, soluble IL-6 receptor (sIL-6r), and TNF-α. Relationships between sex hormones and inflammatory markers were examined by multivariate linear regression analyses adjusted for age, body mass index, smoking, insulin, physical activity, and chronic disease.
RESULTS:

In fully adjusted analyses, SHBG was negatively associated with CRP (P = 0.007), IL-6 (P = 0.008), and sIL-6r (P = 0.02). In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-α (P = 0.0002). The negative relationship between testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no longer significant in a fully adjusted model (P = 0.12). E2 was positively associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models. In a final model including E2, testosterone, and SHBG, and all the confounders previously considered, SHBG (0.23 ± 0.08; P = 0.006) and E2 (0.21 ± 0.08; P = 0.007), but not testosterone (P = 0.21), were still significantly associated with CRP.
CONCLUSION:

In late postmenopausal women not on hormone replacement therapy, SHBG and E2 are, respectively, negative and positive, independent and significant correlates of a proinflammatory state

SHBG, Sex Hormones, and Inflammatory Markers in Older Women

Abstract

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Crossref

Archivio della ricerca - Università degli studi di Napoli Federico II

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Archivio istituzionale della ricerca - Università di Ferrara