Bastard

Bayol

Buckley

Bullo

Caluwaerts

Campion

Canoy

Dandona

Davi

Flora

Furukawa

GREWAL

Hotamisligil

Johnston

Kirk

Mukherjee

Nivoit

R. A. Simmons

Radaelli

Ramsay

Reitman

Rodeheffer

S. Sen

Urakawa

Wagner

Yanes

English

PubMed


                  OBJECTIVE
                  Obesity in pregnancy significantly increases the risk of the offspring developing obesity after birth. The aims of this study were to test the hypothesis that maternal obesity increases oxidative stress during fetal development, and to determine whether administration of an antioxidant supplement to pregnant Western diet-fed rats would prevent the development of adiposity in the offspring.
               
               
                  RESEARCH DESIGN AND METHODS
                  Female Sprague Dawley rats were started on the designated diet at 4 weeks of age. Four groups of animals were studied: control chow (control); control + antioxidants (control+Aox); Western diet (Western); and Western diet + antioxidants (Western+Aox). The rats were mated at 12 to 14 weeks of age, and all pups were weaned onto control diet.
               
               
                  RESULTS
                  Offspring from dams fed the Western diet had significantly increased adiposity as early as 2 weeks of age as well as impaired glucose tolerance compared with offspring of dams fed a control diet. Inflammation and oxidative stress were increased in preimplantation embryos, fetuses, and newborns of Western diet-fed rats. Gene expression of proadipogenic and lipogenic genes was altered in fat tissue of rats at 2 weeks and 2 months of age. The addition of an antioxidant supplement decreased adiposity and normalized glucose tolerance.
               
               
                  CONCLUSIONS
                  Inflammation and oxidative stress appear to play a key role in the development of increased adiposity in the offspring of Western diet-fed pregnant dams. Restoration of the antioxidant balance during pregnancy in the Western diet-fed dam is associated with decreased adiposity in offspring.
               </jats:sec

Sarbattama Sen

Rebecca A. Simmons

Crossref

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Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western Diet–Fed Rats

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2992766

Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western Diet–Fed Rats

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